Korean J Thorac Cardiovasc Surg.  2009 Oct;42(5):610-614.

Visceral Pleural Invasion as a Prognostic Factor for Recurrence in Resected IB Non-small Cell Lung Cancer

• Kim S
• Park KS
• Kum YS
• Lee S
• Bae CH
• Hyun DS

Abstract

BACKGROUND: Several trials have reported on whether adjuvant chemotherapy for resected stage IB non-small cell lung cancer is needed. The aim of our study was to investigate prognostic factors for recurrence to help identify patients who should receive adjuvant chemotherapy. MATERIAL AND METHOD: We reviewed the cases of 48 stage IB non-small cell lung cancer patients between 1997 and 2006. Disease-free survival and overall survival rates were calculated by the Kaplan-Meier method. Univariate analysis was performed with the log rank test and multivariate analysis was done using Cox's proportional hazard model. RESULT: The median follow-up time was 48 months. The overall survival rate was 55.9%, and the disease-free survival rate was 48.6%. Of 8 variables, two factors, visceral pleural invasion and lymphovascular invasion, were prognostic factors of disease-free survival (univariate analysis). Visceral pleural invasion was a significant prognostic factor in multivariate analysis, and overall survival in compared one or more variable such as visceral pleural invasion or, and lymphovascular invasion with the other variables.
CONCLUSION
Visceral pleural invasion was identified as a poor prognostic factor and it may help select which patients will benefit from adjuvant chemotherapy in addition to more comprehensive follow-up.

Keyword

Neoplasm stage; Adjuvant therapy; Visceral pleural invasion

MeSH Terms

Carcinoma, Non-Small-Cell Lung
Chemotherapy, Adjuvant
Disease-Free Survival
Follow-Up Studies
Humans
Multivariate Analysis
Proportional Hazards Models
Recurrence
Survival Rate