J Korean Androl Soc.  1992 Jun;10(1):13-17.

Histologic changes after intracavernous injections of vasactive agents, solutions with defferent osmolarity and pH in the rabbit

• Jung GW
• Oh SS
• Kim YB
• Youn JH

Abstract

We investigated histologic changes following intracavernous injection of vasoactive agents and solutions with different osmolarity and pH in rabbits. Initially, four groups of three rabbits each received intracavernous injections of the following agents once a week for six consecutive weeks: group 1, normal saline 1ml, group 2, papaverine 20mg/ml, group 3, phentolamine 5mg/ml, group 4, PGE1 20 microgram/ml. One week after the last injection, the penises were histologically examined with H-E and Masson's trichrome stain. Next, another four groups of three rabbits each received the following solutions using the previous method: group 1, 320 mosmol/l and pH 2, group 2, 320 mosmol/l and pH 7, group 3, 3200 mosmol/l and pH 2 and group 4, 3200 mosmol/l and pH 7. Moderate to mild fibrosis was found after the injection of papaverine and mild to none after phentolamine and PGE1. Fibrosis was not noted after normal saline as well as solutions with different osmolarity and pH. These findings suggest that penile fibrosis following intracavernous injection results from a property inherent in the injected drug and not from the pH or osmolarity of the solutions.

MeSH Terms

Alprostadil
Fibrosis
Hydrogen-Ion Concentration*
Male
Osmolar Concentration*
Papaverine
Penis
Phentolamine
Rabbits
Alprostadil
Papaverine
Phentolamine