J Asthma Allergy Clin Immunol.  1999 Aug;19(4):566-575.

One Year result of Dermatophagoides farinae antigen - speciffic autologous antibody complex immunotherapy in respiratory allergic patients sensitized to house dust mite

• Park JW
• Hong CS
• Yun YY
• Ko SH
• Kim CW
• Kim KS

Abstract

BACKGROUND: Although good clinical effects have been reported, immunotherapy with house dust mite ( HDM ) antigen - autologous specific antibody complex ( IC - IT ) is not yet accepted as an effective immunomodulating tool in HDM allergic diseases. We aimed to prove the clinical effect of IC - IT in HDM sensitized respiratory allergic subjects. Method : Six HDM sensitized respiratory allergic subjects were enrolled. Autologous D. farinae specific IgG was purified with DEAE ion exchange and affinity chromatography. After one year of IC - IT treatment the clinical effects were analyzed with symptom scores, methacholine PC20, ELISA assay of D. farinae specific antibodies and intradermal skin reactivity. Result : The rhinitis symptom score significantly improved after a one - year administration of IC - IT ( 1.23 +/- 0.30 vs. 0.37 +/- 0.15, p< 0.05), but no significant differences were found in asthma symptom score, intradermal skin reactivity to D. farinae and ELISA optic absorbances of D. farinae specific IgE, IgG, and IgG subclasses. Methacholine PC20 values improved in all 6 patients who were administered with IC - IT ( 0.35 vs. 1.66 mg/ml, p< 0.05 ).
CONCLUSION
IC - IT may be efficient for management of HDM atopic asthma. Further studies are needed before clinical application of IC - IT in house dust mite atopic subjects.

Keyword

immune complex immunotherapy; house dust mite

MeSH Terms

Antibodies
Asthma
Chromatography, Affinity
Dermatophagoides farinae*
Dust*
Enzyme-Linked Immunosorbent Assay
Humans
Immunoglobulin E
Immunoglobulin G
Immunotherapy*
Ion Exchange
Methacholine Chloride
Pyroglyphidae*
Rhinitis
Skin
Antibodies
Dust
Immunoglobulin E
Immunoglobulin G
Methacholine Chloride