Gut Liver.  2012 Jul;6(3):321-327.

The COX-2-1195AA Genotype Is Associated with Diffuse-Type Gastric Cancer in Korea

• Shin WG
• Kim HJ
• Cho SJ
• Kim HS
• Kim KH
• Jang MK
• Lee JH
• Kim HY

Abstract

BACKGROUND/AIMS
The potential role of the cyclooxygenase (COX)-2 polymorphism has been reported in relation to the risk of gastrointestinal tract malignancies. Therefore, we investigated whether COX-2 polymorphisms are associated with the risk of gastric cancer (GC) in Korea, one of the areas with a high prevalence of this condition.
METHODS
We evaluated the genotypic frequencies of COX-2-765 and -1195 in 100 peptic ulcer patients, 100 GC patients, and 100 healthy controls. The polymorphisms of the COX-2-765 and -1195 genes were analyzed by polymerase chain reaction and restriction fragment length polymorphisms.
RESULTS
The frequencies of the COX-2-1195 GG, GA, and AA genotype were 20%, 60%, and 20% in intestinal-type GC and 8%, 48%, and 44% in diffuse-type GC, respectively (p=0.021). There were no significant differences in the frequency of COX-2-765 genotypes between intestinal-type GC and diffuse-type GC (p=0.603). Age- and sex-adjusted logistic regression analysis showed that the COX-2-1195 AA genotype was the independent risk factor of diffuse-type GC compared with the COX-2-1195 GG genotype (p=0.041; odds ratio, 6.22; 95% confidence interval, 1.077 to 35.870).
CONCLUSIONS
The COX-2-1195 AA genotype may render subjects more susceptible to diffuse-type GC.

Keyword

Stomach neoplasms; Diffuse type; COX-2; Polymorphism

MeSH Terms

Gastrointestinal Tract
Genotype
Humans
Korea
Logistic Models
Odds Ratio
Peptic Ulcer
Polymerase Chain Reaction
Prevalence
Prostaglandin-Endoperoxide Synthases
Risk Factors
Stomach Neoplasms
Prostaglandin-Endoperoxide Synthases