Exp Neurobiol.  2011 Jun;20(2):116-122. 10.5607/en.2011.20.2.116.

Interactions of Dopamine D1 and N-methyl-D-Aspartate Receptors are Required for Acute Cocaine-Evoked Nitric Oxide Efflux in the Dorsal Striatum

• Lee DK
• Ahn SM
• Shim YB
• Koh WC
• Shim I
• Choe ES

• KMID: 2052824
• DOI: http://doi.org/10.5607/en.2011.20.2.116

Abstract

Alterations in nitric oxide (NO) release in response to psychostimulants in the striatum cause a plastic change contributing to the development and expression of addiction. In this study, regulation of NO efflux evoked by acute cocaine in the dorsal striatum was investigated using real-time detection of NO in vivo. We found that acute systemic injection of cocaine (20 mg/kg) increased NO efflux, which was reduced by the intrastriatal infusion of the dopamine D1 receptor antagonist, SCH23390 (7.5 nmol), and the dopamine D2 receptor agonist, quinpirole (5 nmol). Increased levels of NO efflux by acute cocaine were also reduced by the intrastriatal infusion of the N-methyl-D-aspartate (NMDA) receptor antagonists, MK801 (2 nmol) and AP5 (2 nmol). These findings suggest that interactions of dopamine D1 receptors and NMDA receptors after acute exposure to cocaine participate in the upregulation of NO efflux in the dorsal striatum.

Keyword

addiction; caudate-putamen; dopamine; glutamate; psychostimulant

MeSH Terms

Benzazepines
Cocaine
Dizocilpine Maleate
Dopamine
Glutamic Acid
N-Methylaspartate
Nitric Oxide
Plastics
Quinpirole
Receptors, Dopamine D1
Receptors, Dopamine D2
Receptors, N-Methyl-D-Aspartate
Up-Regulation
Benzazepines
Cocaine
Dizocilpine Maleate
Dopamine
Glutamic Acid
N-Methylaspartate
Nitric Oxide
Plastics
Quinpirole
Receptors, Dopamine D1
Receptors, Dopamine D2
Receptors, N-Methyl-D-Aspartate