Nucl Med Mol Imaging.
2010 Apr;44(1):39-44.
Tumor Burden Assessed by the Maximum Standardized Uptake Value and Greatest Diameter on FDG-PET Predicts Prognosis in Untreated Diffuse Large B-cell Lymphoma
- Affiliations
-
- 1Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 166 Gumi-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707, Korea. wwlee@snu.ac.kr
- 2Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Korea.
- 3Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, Korea.
- 4Department of Nuclear Medicine, Cho Ray Hospital, Ho Chi Minh City, Viet Nam.
- 5Department of Nuclear Medicine Diagnosis and Therapy, Cairo University, Cairo, Egypt.
Abstract
- PURPOSE
It is uncertain whether the tumor burden as assessed using FDG-PET has prognostic significance in newly diagnosed diffuse large B-cell lymphoma (DLBCL). The authors undertook this study to determine whether a parameter that reflects both FDG uptake magnitude and the greatest tumor diameter is a prognostic indicator in DLBCL.
MATERIALS AND METHODS
Forty-two DLBCL patients (age, 57.4+/-15.5 years; male/female=25/17; stage I/II/III/IV=5/17/10/10) who underwent FDG-PET before chemotherapy were enrolled. A lesion with the highest maximum standardized uptake value (MaxSUV) on the PET image was selected, and size-incorporated MaxSUV (SIMaxSUV) of mass was calculated as MaxSUV x greatest diameter (mm) on the transaxial PET image. Median follow-up duration was 20.0 months.
RESULTS
Twelve (28.6%=12/42) patients experienced disease progression, and 10 (23.8%=10/42) died during follow-up. Among six variables [Ann Arbor stage, %Ki-67 expression, International Prognostic Index (IPI), MaxSUV, greatest diameter, and SIMaxSUV] investigated, only SIMaxSUV was found to be a single determinant of progression-free and overall survivals by multivariate analyses (p<0.05).
CONCLUSION
These results suggest that SIMaxSUV, a new FDG-PET parameter that incorporates FDG uptake magnitude and the greatest tumor diameter, may be a useful indicator of prognosis in untreated DLBCL.