Tuberc Respir Dis.  1996 Aug;43(4):527-535. 10.4046/trd.1996.43.4.527.

Changes of Serum soluble ICAM-1 levels in Patients with Lung Cancer

• Yoo WH
• Lee YC
• Rhee YK

• KMID: 2049932
• DOI: http://doi.org/10.4046/trd.1996.43.4.527

Abstract

BACKGROUND
Cell adhesion molecules have been implicated in the various stages of tumor progression and metastasis. ICAM-1 plays a important roles in cell-cell interactions in inflammatory and immune response of several diseases. Recently, elevated levels of sICAM-1 in circulation was reported as association with liver metastasis in gastric, colonic, gall bladder and pancreatic cancer, with reduced survival in malignant melanoma. This study was performed to measure the sICAM-1 in patients with lung cancer and to evaluate the relations between staging of lung cancer and level of sICAM-1.
METHODS
Serum sICAM-1 was measured in 36 patients with lung cancer according to the pathologic types and clinical staging before therapy and in 8 controls with ICAM-1 ELISA kit.
RESULTS
Serum sICAM-1 levels were elevated in patients with lung cancer except small cell type. Also progression and metastasis of lung cancer associated with elevation of sICAM-1 levels.
CONCLUSION
These results suggest that higher levels of serum ICAM-1 reflect the progression and metastasis of lung cancer and it may be used as a marker with diagnostic and prognostic significance.

Keyword

ICAM-1; Lung cancer

MeSH Terms

Cell Adhesion Molecules
Colon
Enzyme-Linked Immunosorbent Assay
Humans
Intercellular Adhesion Molecule-1*
Liver
Lung Neoplasms*
Lung*
Melanoma
Neoplasm Metastasis
Pancreatic Neoplasms
Urinary Bladder
Cell Adhesion Molecules
Intercellular Adhesion Molecule-1