Clin Pediatr Hematol Oncol.
2010 Apr;17(1):69-75.
A Case of Infantile Hepatic Hemangioendothelioma Successfully Treated with Interferon-alpha
- Affiliations
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- 1Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. hl.jung@samsung.com
Abstract
- Infantile hemangioendothelioma is a rare benign, but intermediate to aggressive vascular tumor with potentially life-threatening complications such as high output congestive heart failure or Kasabach-Merritt syndrome. IHE is the most common hepatic vascular tumor and the third most common hepatic tumor in children, usually developing in infants less than 6 months of age. Serum alpha-fetoprotein level has been used as an important tumor marker for malignant hepatic tumors such as hepatoblastoma, hepatocellular carcinoma, and germ cell tumors. Steroids and interferon-alpha are two commonly used agents for medical treatment in IHE. We report a 5-month-old female infant with multiple hepatic hemangioendotheliomas associated with elevation of serum alpha-fetoprotein level, who was successfully treated with interferon-alpha.
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