Clin Pediatr Hematol Oncol.  2010 Apr;17(1):59-63.

A Case of Concurrent Cholestatic Jaundice and Hemolytic Anemia Due to Epstein-Barr Virus Infection

• Hong YJ
• Choi HS
• Hwang HS
• Lee SY
• Chung SY
• Kang JH
• Jeong DC

Abstract

The patients infected with Epstein-Barr virus (EBV) experienced asymptomatic or mild flu-like illness. Most of symptoms with EBV infection were disappeared within several weeks, although there were various clinical manifestations. Jaundice with elevated liver enzymes was shown about 5~25%, but hemolytic anemia was rare during EBV infection. Some cases due to EBV infection had been persistent or aggravated course of hemolytic anemia. A twelve-year-old boy was admitted due to fever, and jaundice. Total bilirubin with direct bilirubin was elevated with moderately increased aminotransferase levels. He developed mild hemolytic anemia with positive Coomb's test and high titer of cold agglutinin during hospitalization. The symptoms were spontaneously improved with conservative care. We report a case of concurrent cholestatic jaundice with hemolytic anemia during acute EBV infection.

Keyword

Epstein-Barr virus; Cholestatic jaundice; Hemolytic anemia

MeSH Terms

Anemia, Hemolytic
Bilirubin
Cold Temperature
Coombs Test
Epstein-Barr Virus Infections
Fever
Herpesvirus 4, Human
Hospitalization
Humans
Jaundice
Jaundice, Obstructive
Liver
Bilirubin