Korean J Hematol.  1998 Oct;33(3):438-442.

A Case of Epstein-Barr Virus Infection Presented as Evans Syndrome

Affiliations
  • 1Department of Internal Medicine, Kyungpook National University, School of Medicine, Taegu, Korea.

Abstract

Evans syndrome refer to autoimmune hemolytic anemia accompanied by thrombocytopenia. The etiologic factors of Evans syndrome are unknown but viral infections such as Epstein-Barr virus and cytomegalovirus are suggested. Epstein-Barr virus (EBV) infection is an acute illness characterized clinically by fever, sore throat, and lymphadenopathy; serologically by the transient positive heterophil antibody; and hematologically by mononuclear leukocytosis with atypical lymphocytosis. We experienced a case of Epstein-Barr virus infection presented as Evans syndrome. Epstein-Barr virus infection was diagnosed by positive heterophil antibody and EBV viral capsid antigen IgM. Autoimmune hemolytic anemia and immune thrombocytopenic purpura were completely resolved by steroid therapy.

Keyword

Evans syndrome; Epstein-Barr virus

MeSH Terms

Anemia, Hemolytic, Autoimmune
Capsid
Cytomegalovirus
Fever
Herpesvirus 4, Human*
Immunoglobulin M
Leukocytosis
Lymphatic Diseases
Lymphocytosis
Pharyngitis
Purpura, Thrombocytopenic, Idiopathic
Thrombocytopenia
Immunoglobulin M
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