Clin Pediatr Hematol Oncol.  2010 Apr;17(1):28-35.

A Clinical Characteristics and Courses of 2009 Pandemic Influenza A (H1N1) Virus Infections in Pediatric Hematology Oncology Patients

• Na HR
• Pai KS
• Lee SY
• Park JE

Abstract

PURPOSE
Recently, we have observed 2009 pandemic Influenza A (H1N1) virus infections in pediatric hematology oncology patients during the 2009 H1N1 flu pandemic. The aim of this study is to estimate the clinical characteristics and courses of pediatric hematology oncology patients with 2009 Influenza A (H1N1) virus infection in Ajou University Hospital.
METHODS
We analysed age, sex, underlying disease, clinical characteristics and courses of the patients who were diagnosed as 2009 Influenza A (H1N1) virus infection from September 2009 to March 2010, reviewing their medical records.
RESULTS
Among the 57 patients who were admitted in pediatric hematology oncology department with suspicious Influenza A (H1N1) virus infection, 11 patients have been diagnosed as 2009 Influenza A (H1N1) virus infection by the method of real-time PCR. The underlying hematologic diseases consist of acute lymphoblastic leukemia 4, aplastic anemia 2, acute myelocytic leukemia 1, non-Hodgkin's lymphoma 1, immune thrombocytopenic purpura 2, congenital neutropenia 1, and Langerhans' cell histiocytosis 1. The fever subsided within 48 hours of Tamiflu(R) (Roche, USA) administration in 10 patients, except for one patient whose fever subsided without Tamiflu(R) administration. Among the 11 hematology oncology patients who have been diagnosed as 2009 Influenza A (H1N1) virus infection, 10 patients (90%) were improved without any complication.
CONCLUSION
When we reviewed the medical records of the 11 hematology-oncology patients who were diagnosed 2009 Influenza A (H1N1) virus infection, it was observed that most of them recovered without complications after adminstration of Tamiflu(R), combined with antibiotics or G-CSF treatment.

Keyword

2009 Influenza A (H1N1) virus; Pediatric Hematology Oncology patients; Tamiflu(R)

MeSH Terms

Anemia, Aplastic
Anti-Bacterial Agents
Fever
Granulocyte Colony-Stimulating Factor
Hematologic Diseases
Hematology
Histiocytosis
Humans
Influenza, Human
Leukemia
Lymphoma, Non-Hodgkin
Medical Records
Neutropenia
Pandemics
Purpura, Thrombocytopenic, Idiopathic
Real-Time Polymerase Chain Reaction
Viruses
Anti-Bacterial Agents
Granulocyte Colony-Stimulating Factor