Brain Neurorehabil.  2011 Sep;4(2):121-125. 10.12786/bn.2011.4.2.121.

Effects of Botulinum Toxin A Injection into Salivary Glands of Patients with Brain Lesion Suffering from Posterior Drooling

• Lee ZI
• Park DH
• Jo DH
• Choi WD
• Byun SD

• KMID: 2048466
• DOI: http://doi.org/10.12786/bn.2011.4.2.121

Abstract

OBJECTIVE
The aim of the study was to evaluate the effectiveness of ultrasouond-guided salivary gland injection of botulinum toxin A (BTX-A) for posterior drooling. METHOD: 11 patients with brain lesion (9 cerebral palsy, 1 hypoxic ischemic encephalopathy and 1 mental retardation) with posterior drooling (an initial PDAS score greater than 2) and related pulmonary problems were recruited. Drooling severity was measured at baseline, 4 weeks, 3 months and 6 months after botulinum toxin A injection, by using Teacher Drooling Scale (TDS), Visual Analogue Scales (VAS), Drooling Score System (DSS)-severity, frequency and Posterior Drooling/Aspiration System (PDAS).
RESULTS
The TDS, DSS-severity, DSS-frequency, VAS, PDAS were significantly reduced at 4 weeks and 3 months after BTX-A injection into salivary glands compared to pre-injection (p<0.05). However, there were no significant changes at 6 months compared to pre-injection level.
CONCLUSION
BTX-A injection into salivary glands may improve anterior drooling in patients with brain lesions. Furthermore BTX-A injection into salivary glands may also decrease the posterior drooling which might related to respiratory symptoms in aspiration pneumonia.

Keyword

botulinum toxin type A; drooling; salivary glands

MeSH Terms

Botulinum Toxins
Botulinum Toxins, Type A
Brain
Cerebral Palsy
Humans
Hypoxia-Ischemia, Brain
Pneumonia, Aspiration
Salivary Glands
Sialorrhea
Sorbitol
Stress, Psychological
Tyramine
Weights and Measures
Botulinum Toxins
Botulinum Toxins, Type A
Sorbitol
Tyramine

Figure

• 

  Fig. 1 These figure shows the ultrasound guided botulinum toxin injection into salivary gland. Submandibular gland before botulinum toxin injection (A) after botulinum toxin injection (B).

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