Clin Exp Reprod Med.  2011 Jun;38(2):98-102. 10.5653/cerm.2011.38.2.98.

Pioglitazone treatment decreases follicular fluid levels of tumor necrosis factor-alpha and interleukin-6 in patients with polycystic ovary syndrome

• Kim CH
• Ahn JW
• You RM
• Kim SH
• Chae HD
• Kang BM

• KMID: 2045702
• DOI: http://doi.org/10.5653/cerm.2011.38.2.98

Abstract

OBJECTIVE
To investigate the effects of pioglitazone on controlled ovarian stimulation (COS), IVF outcomes, and follicular fluid (FF) cytokine concentrations in patients with polycystic ovary syndrome (PCOS).
METHODS
Eighty-six infertile patients with PCOS resistant to clomiphene citrate were randomized to receive pioglitazone (30 mg/day) or placebo on the starting day of oral contraceptive (OC) pretreatment, followed by an IVF protocol using a GnRH antagonist. Pioglitazone or placebo was administered once daily from the starting day of OC to the day of hCG injection.
RESULTS
Total dose and days of recombinant follicle-stimulating hormone administered, and the numbers of retrieved and mature oocytes, were significantly lower in the pioglitazone group than in the control group. FF tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) concentrations at oocyte retrieval were also significantly lower in the pioglitazone group. The clinical pregnancy rate was higher and the incidence of severe ovarian hyperstimulation syndrome was lower in the pioglitazone group, but the differences were not statistically significant.
CONCLUSION
Pioglitazone reduces FF TNF-alpha and IL-6 levels, and may improve ovarian response to COS in patients with PCOS.

Keyword

Pioglitazone; Follicular Fluid; Tumor Necrosis Factor-alpha; Interleukin-6; In Vitro Fertilization; Polycystic Ovary Syndrome; Human

MeSH Terms

Clomiphene
Female
Fertilization in Vitro
Follicle Stimulating Hormone
Follicular Fluid
Gonadotropin-Releasing Hormone
Humans
Incidence
Interleukin-6
Oocyte Retrieval
Oocytes
Ovarian Hyperstimulation Syndrome
Ovulation Induction
Polycystic Ovary Syndrome
Pregnancy Rate
Thiazolidinediones
Tumor Necrosis Factor-alpha
Clomiphene
Follicle Stimulating Hormone
Gonadotropin-Releasing Hormone
Interleukin-6
Thiazolidinediones
Tumor Necrosis Factor-alpha