Korean J Anesthesiol.  2006 Oct;51(4):395-399. 10.4097/kjae.2006.51.4.395.

The Effect of H1-Receptor Antagonist on Hemodynamic Change during Anesthesia

• Hahm TS
• Kim CS
• Koo MS
• Shin BS
• Hwang HY
• Lee SM
• Cho HS

• KMID: 2045353
• DOI: http://doi.org/10.4097/kjae.2006.51.4.395

Abstract

baseline for safe use of a drug.
RESULTS
SVR and PVR failed to show statistically significant changes. Heart rates were increased only at 2 minute after administration of chlorpheniramine maleate. Blood pressures were increased but returned to basal level within 4 minutes. Cardiac output showed statistically significant increase until 8 minutes. However, the changes of hemodynamic values were maintained within 20% of basal levels.
CONCLUSIONS
Chlorpheniramine maleate is observed to cause statistically significant hemodynamic change after intravenous administration during anesthesia. But the changes were within 20% of basal levels, and we can safely use chlorpheniramine maleate 8 mg IV in the view of hemodynamic changes.

Keyword

antihistamine; chlorpheniramine maleate; hemodynamic change

MeSH Terms

Administration, Intravenous
Anesthesia*
Cardiac Output
Chlorpheniramine
Heart Rate
Hemodynamics*
Chlorpheniramine