J Korean Acad Fam Med.
2005 Feb;26(2):88-95.
Change of Antibiotic Sensitivities to Causative Organisms of Urinary Tract Infection in Out Patients 2 years Before and After the Separation of Prescription and Dispensing Medicines
- Affiliations
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- 1Department of Family Medicine, GangNeung Asan Hospital, College of Medicine, Ulsan University, Korea. omk@knh.co.kr
- 2Department of Internal Medicine, GangNeung Asan Hospital, College of Medicine, Ulsan University, Korea.
- 3Department of Family Medicine, Chungnam National University Hospital, Korea.
Abstract
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BACKGROUND: The overuse and misuse of antimicrobial agents and their resultant emergence of resistant microorganisms have made choices regarding antimicrobial therapy more difficult .Therefore,a new system that separated prescribing and dispensing medicine began on July 1,1997 to prevent overuse and misuse of medicine.We studied to evaluate changes of antibiotic sensitivities to causative microorganisms of urinary tract infection 2 years before and after the new medical system.
METHODS
During each 2 years before and after the new medical system,we analyzed antibiotic sensitivities of causative microorganisms for urinary tract infection among the 447 out-patients who visited a hospital in GangNeung.The diagnosis of urinary tract infection was based on greater than 105 CFU (Colony For Unit)per ml.urine.
RESULTS
The most common pathogenic microorganisms as E.coli (76.5%),followed by Klebsiella pneumoniae (5.1%),and Proteus mirabilis (3.6%)in urine culture. A first generation cephalosporin,cephalothin,against E.coli, had more significant sensitivity after the introduction of the new medical system (52.6%)than before (33.9%),especially in the 80th decade (P=0.023) and in females (P<0.001).Also,trimethoprim/sulfamethoxazole against E.coli showed signifcant improving sensitivity (P=0.025).
CONCLUSION
There was little change of antibiotic sensitivity of urinary tract infection in out-patients before and after the new medical system in cephalothin and trimethoprim/sulfamethoxazole against E.coli. The change of antibiotic sensitivities will require further observation for a longer term after the introduction of the new medical system.
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