J Korean Surg Soc.  2010 Dec;79(Suppl 1):S62-S66. 10.4174/jkss.2010.79.Suppl1.S62.

Infantile Fibrosarcoma in Neonate

• Nam SH
• Cho MJ
• Kim DY
• Kim SC
• Kim IK

• KMID: 2040556
• DOI: http://doi.org/10.4174/jkss.2010.79.Suppl1.S62

Abstract

Infantile fibrosarcoma is a rare malignant soft tissue tumor occurring especially in newborn and young children under 2 years. We experienced three cases of infantile fibrosarcoma presenting in the neonatal period. Case 1 presented with a multiseptated cystic mass on his left thigh at birth that was diagnosed as lymphangioma. After picibanil injection, we noted the size of the mass doubled and a solid lesion was prominent in the magnetic resonance image. Case 2 was found to have a reddish mass on his lower back mimicking hemangioma. Over 2 weeks, the mass grew rapidly with internal hemorrhaging. Case 3 was noted to have an encircling mass around the splenic flexure, which developed into congenital bowel obstruction. All of the tumors were resected completely, but microscopic resection margin was not clear in two patients. The two patients received adjuvant chemotherapy and all patients are well without evidence of recurrence.

Keyword

Infantile fibrosarcoma; Congenital lymphangioma; Congenital hemangioma; Congenital bowel obstruction

MeSH Terms

Chemotherapy, Adjuvant
Child
Colon, Transverse
Fibrosarcoma
Hemangioma
Humans
Infant, Newborn
Lymphangioma
Magnetic Resonance Spectroscopy
Parturition
Picibanil
Recurrence
Thigh
Picibanil

Figure

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  Fig. 1 (A) Ultrasonography shows multiseptated cystic mass with internal hemorrhage on the left thigh. (B) Coronal T2 weighted MR image reveals a huge mass with remarkable solid portion and lesional heterogeneity. (C) Cut surface appearance of gross specimen shows grayish white solid mass with internal hemorrhage and necrosis. (D) Microscopic examination shows herringbone pattern of spindled fibrosarcoma cell with high cellularity and mitosis (H&E stain, ×400).

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  Fig. 2 (A) Sagittal T2 weighted MR image reveals a hyperintense homogenous, well defined mass on the back without connection to spinal canal. (B) The exophytic hard mass is rapidly growing with the overlying skin stretching with ulceration.

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  Fig. 3 Abdominal CT scan shows a 3.5 cm hyperdense mass at the splenic flexure, which developed bowel obstruction.

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