Korean J Pathol.
1998 Apr;32(4):266-272.
Cyclin D1 Expression in 101 Cases of Breast Carcinoma
- Affiliations
-
- 1Department of Pathology, College of Medicine, Hallym University, Seoul, Korea.
- 2Department of Pathology, Dankook University, College of Medicine, Korea.
- 3Department of Surgery, Dankook University, College of Medicine, Korea.
- 4Department of Diagnostic Pathology, Sung Kyun Kwan University, College of Medicine, Samsung Seoul Hospital, Korea.
Abstract
- Cyclin D1, a cell cycle regulator essential for G1 phase progression, is a candidate proto-oncogene implicated in pathogenesis of several human carcinomas including breast carcinoma. We studied the cyclin D1 expression in 101 cases of primary breast carcinoma tissues. The overexpression of cyclin D1 was immunohistochemically demonstrated in 34 (37.8%) of 90 cases of invasive breast carcinoma. Positive cyclin D1 staining was seen in 32 of 79 invasive ductal carcinomas, and 2 of 3 mucinous carcinomas. All 5 medullary carcinomas, 2 invasive lobular carcinomas, and 1 metaplastic carcinoma were negative. Cyclin D1 overexpression was observed in 9 of 11 ductal carcinoma in situ (DCIS). Normal epithelial components, either ductal or lobular, were not immunoreactive for cyclin D1. No significant correlations were observed between cyclin D1 immunoreactivity and other parameters including tumor size, clinical stage, nuclear or histologic grades, lymphatic or angioinvasion, lymph node metastasis, and immunohistochemical status of progesterone receptor, p53 and c-erbB-2. The overexpression of cyclin D1 was positively correlated with estrogen receptor status (p=0.025). Based on our results, the cyclin D1 protein aberration may play a role in tumorigenesis of breast carcinoma, but does not seem to have prognostic value in invasive breast carcinoma without hormonal treatment.
MeSH Terms
-
Adenocarcinoma, Mucinous
Breast Neoplasms*
Breast*
Carcinogenesis
Carcinoma, Ductal
Carcinoma, Intraductal, Noninfiltrating
Carcinoma, Lobular
Carcinoma, Medullary
Cell Cycle
Cyclin D1*
Cyclins*
Estrogens
G1 Phase
Humans
Lymph Nodes
Neoplasm Metastasis
Proto-Oncogenes
Receptors, Progesterone
Cyclin D1
Cyclins
Estrogens
Receptors, Progesterone
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