Korean J Anesthesiol.  2002 Mar;42(3):355-367. 10.4097/kjae.2002.42.3.355.

Changes in Hemodynamics and Local Myocardial Perfusion in the Acute Phase of Coronary Reperfusion by Using Nicardipine in Korean Mongrel Dogs

• Lee HR
• Sin WH
• Jang YH
• Kim AR
• Kim JM
• Cheun JK
• Yoo HK
• Kim YN

• KMID: 2031952
• DOI: http://doi.org/10.4097/kjae.2002.42.3.355

Abstract

BACKGROUND: The measurement of perfusion is very important to understanding the physiology in the ischemic and reperfused tissue. However, no studies have been reported using a beating heart with a real time-continuous perfusion measurement system (QFlow(TM)400) to check local tissue perfusion so far. In this study, the changes in hemodynamics and local myocardial perfusion (LMP) after coronary reperfusion with nicardipine (a calcium channel blocker) administration were evaluated.
METHODS
A total of 10 mongrel dogs were divided into two groups; group I (control group, n = 5), group II (nicardipine group, n = 5). After femoral arterial, pulmonary arterial and left ventricular catheterization, a left thoracotomy was performed. Next, the left anterior descending coronary artery (LAD) was exposed, and a thermal diffusion microprobe was inserted in the myocardium to measure LMP.
RESULTS
In group II, blood pressure and systemic vascular resistance after LAD reperfusion were significantly decreased compared to group I. Cardiac output and stroke volume were more rapidly increased in group II, while left ventricular stroke work was decreased in group II. In group I, the LMP after LAD reperfusion did not recover to the baseline level, but the LMP did recover 20 minutes after LAD reperfusion and was increased more compared to the baseline level at 30 minutes after LAD reperfusion in group II. There were no significant differences in dP/dt between the two groups.
CONCLUSIONS
We found that the LMP did not recover to the baseline level in the early state of LAD reperfusion; however, nicardipine administration increased the LMP after the early reperfusion period. Cardiac output and stroke volume were also more rapidly increased when nicardipine was administrated.

Keyword

Myocardial perfusion; nicardipine; reperfusion

MeSH Terms

Animals
Blood Pressure
Calcium Channels
Cardiac Output
Catheterization
Catheters
Coronary Vessels
Dogs*
Heart
Hemodynamics*
Myocardial Reperfusion*
Myocardium
Nicardipine*
Perfusion*
Physiology
Reperfusion
Stroke
Stroke Volume
Thermal Diffusion
Thoracotomy
Vascular Resistance
Calcium Channels
Nicardipine