Korean J Anesthesiol.  2004 Apr;46(4):467-474. 10.4097/kjae.2004.46.4.467.

The Systemic Hemodynamic and Renal Effects of Nicardipine Administration Followed by Supraceliac Aortic Cross Clamping and Unclamping in Experimental Dogs

• Hong JH
• Choe US
• Bae JI
• Kim JM
• Kim AR
• Jang YH

• KMID: 2299060
• DOI: http://doi.org/10.4097/kjae.2004.46.4.467

Abstract

BACKGROUND
The incidence of renal insufficiency is reported about 18-27% during the thoracoabdominal aneurysm surgery. The possible mechanisms are reduction and maldistribution of renal blood flow, activation of renin angiotensin system, release of various mediators. In this study, we observed the effect of nicardipine, one of the calcium channel blockers that commonly used, on the systemic hemodynamics and the renal fuctions.
METHODS
A total of 13 mongrel dogs were divided into two groups: control group (C, n = 7), nicardipine administration group (N, n = 6). After brachial arterial and Swan-Ganz catheterization, midline abdominal incision was made. For the aortic cross clamping the supraceilac aorta was exposed and the doppler flowmeter probe was placed on the left renal artery. The thermal diffusion microprobe was inserted in the renal parenchyme to measure local renal perfusion. At sixty minutes after aortic cross clamping, systemic hemodynamic data, renal blood flow and local renal perfusion were measured and at 1, 2, 3, 4, 5 and 6 hours after unclamping the same parameters were measured.
RESULTS
There were no differences on renal blood flow, renal perfusion and oxygen extraction ratio between two groups. The renal blood flow and renal perfusion did not recover to the baseline level after unclamping in both groups. The plasma renin activity, serum creatinine concentration and cystatin-c did not show any difference between groups respectively.
CONCLUSIONS
We concluded that the administration of nicardipine after supraceliac aortic unclamping to improve the renal function was not effective in experimental dogs.

Keyword

local renal perfusion; nicardipine; renal blood flow; renal insufficiency

MeSH Terms

Aneurysm
Animals
Aorta
Calcium Channel Blockers
Catheterization, Swan-Ganz
Constriction*
Creatinine
Dogs*
Flowmeters
Hemodynamics*
Incidence
Nicardipine*
Oxygen
Perfusion
Plasma
Renal Artery
Renal Circulation
Renal Insufficiency
Renin
Renin-Angiotensin System
Thermal Diffusion
Calcium Channel Blockers
Creatinine
Nicardipine
Oxygen
Renin