Korean J Anesthesiol.  2007 Feb;52(2):202-211. 10.4097/kjae.2007.52.2.202.

The Effect of Fenoldopam Administration Followed by Unclamping of Supraceliac Aortic Cross-Clamping on Renal Ischemic Injury

• Yoo JG
• Park HR
• Lee YC
• Kim JM
• Jang YH
• Kim AR
• Bae JI
• Hong JH

• KMID: 2236624
• DOI: http://doi.org/10.4097/kjae.2007.52.2.202

Abstract

BACKGROUND
The overall rate of renal complication after surgery on the suprarenal aorta remains high. In this study, the changes in renal blood flow (RBF), urinary oxygen tension (PuO2), renal vascular resistance (RVR), and urinary volume following fenoldopam administration were investigated in supraceliac aortic cross-clamping and unclamping animal model.
METHODS
Twelve dogs were divided into two groups; control group (n = 6), fenodopam group (n = 6). After brachial, femoral, and pulmonary arterial catheterization, midline abdominal incision was made. For the aortic cross-clamping the supraceliac aorta was exposed. A doppler flowmeter probe was placed around right renal artery. A ureteral catheter was positioned at the right renal pelvis to measure urine volume and urinary oxygen tension (PuO2). In fenoldopam group, 0.5microgram/kg/min of fenoldopam was administered immediately before suprarenal aortic reperfusion. Systemic hemodynamics, renal blood flow, renal vascular resistance, PuO2, and urine volume were compared between two groups.
RESULTS
The systemic hemodynamics were not significantly different between the two groups throughout the experiment. After aortic reperfusion, the RVR significantly increased in control group, but the RVR in fenoldopam group remained to baseline level. The urine output, RBF, and PuO2 significantly increased in fenoldopam group compared to control group. BUN and serum creatinine were not different between the two groups.
CONCLUSIONS
High dose of fenoldopam administration reverse ischemic renal insufficiency after supraceliac aortic cross clamping.

Keyword

aortic cross clamping; fenoldopam; ischemic renal injury; reperfusion

MeSH Terms

Animals
Aorta
Catheterization
Catheters
Constriction
Creatinine
Dogs
Fenoldopam*
Flowmeters
Hemodynamics
Kidney Pelvis
Models, Animal
Oxygen
Renal Artery
Renal Circulation
Renal Insufficiency
Reperfusion
Urinary Catheters
Vascular Resistance
Creatinine
Fenoldopam
Oxygen