Korean J Anesthesiol.  2009 Jan;56(1):6-10. 10.4097/kjae.2009.56.1.6.

Effect of fentanyl on hemodynamic changes connected with a thigh tourniquet during knee arthroscopic surgery

• Lee YS
• Kim JH
• Cha MH
• Min DJ
• Kim WY
• Chang MS
• Park YC

• KMID: 2031855
• DOI: http://doi.org/10.4097/kjae.2009.56.1.6

Abstract

BACKGROUND: The use of a tourniquet can produce pain and increase in blood pressure. It is known that fentanyl reduces central sensitization, however its effect on blood pressure increase due to tourniquet is unknown. So we investigated the effect of fentanyl on tourniquet-induced changes of mean arterial blood pressure (MBP), heart rate (HR), and cardiac index (CI).
METHODS
ASA physical status I and II, who were scheduled for knee arthroscopic surgery using a tourniquet, were assigned into control (n = 30) and fentanyl group (n = 30). Anesthesia was maintained with enflurane, N2O and O2. Fentanyl was injected 1.5 ug/kg at 10 min before inflation of the tourniquet in the fentanyl group. Changes of the MBP, HR, CI were measured before and 10, 20, 30, 40, 50, 60 min after inflation of the tourniquet.
RESULTS
There were no differences in the baseline values. MBP was increased at 40, 50, 60 min in the control group. At 60 min, MBP was lower in the fentanyl than the control group. HR was decreased at 10 min in the fentanyl group. CI was decreased in all groups after tourniquet inflation. At 60 min, CI was more decreased in the control than the fentanyl group.
CONCLUSIONS
Fentanyl injection prior to tourniquet inflation can attenuate the tourniquet induced hemodynamic changes in the knee arthroscopic surgery patients.

Keyword

Fentanyl; Hemodynamic change; Tourniquet

MeSH Terms

Anesthesia
Arterial Pressure
Arthroscopy
Blood Pressure
Central Nervous System Sensitization
Enflurane
Fentanyl
Heart Rate
Hemodynamics
Humans
Inflation, Economic
Knee
Thigh
Tourniquets
Enflurane
Fentanyl