Korean J Clin Pathol.  1999 Oct;19(5):486-490.

Coagulation Factor VII Activity and R353Q Polymorphism in Coronary Artery Disease

• Kim HK
• Song KS
• Park Q
• Sung JY
• Park YS
• Shim W
• Jee SH

Abstract

BACKGROUND
High plasma levels of coagulation factor VII (FVII) are associated with a risk of coronary artery disease (CAD). Plasma FVII levels are influenced by environmental and genetic factors. We investigated whether the risk of CAD is associated with R353Q polymorphism and whether this polymorphism is associated with factor VII activity
METHODS
We analysed plasma levels of FVII:C and FVII genotype for R353Q polymorphism in 85 CAD patients, 63 healthy controls, and 27 patient controls. And total cholesterol, HDL-cholesterol and triglyceride were measured in the same study populations.
RESULTS
There was no difference among CAD patients, healthy controls, and patient controls in plasma levels of FVII:C. Allele Q of the R353Q polymorphism was less frequent in CAD patients (11.8%) than healthy controls (17.5%), although the difference was not statistically significant. Patients with the RQ genotype had a decreased risk of CAD (odds ratio, 0.29). There was no association between R353Q polymorphism and plasma levels of FVII:C. Plasma levels of FVII:C were positively correlated with total cholesterol and triglyceride.
CONCLUSIONS
Our findings suggest that R353Q polymorphism may confer significant protection from CAD and that plasma levels of FVII:C may influenced by total cholesterol and triglyceride.

Keyword

Factor VII; R353Q polymorphism; Coronary artery disease

MeSH Terms

Alleles
Blood Coagulation Factors*
Cholesterol
Coronary Artery Disease*
Coronary Vessels*
Factor VII*
Genotype
Humans
Plasma
Triglycerides
Blood Coagulation Factors
Cholesterol
Factor VII