Korean J Biol Psychiatry.
2012 Aug;19(3):140-145.
Association Analyses of ST8SIA2 Genetic Polymorphisms with Schizophrenia in the Korean Population
- Affiliations
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- 1Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea. hongks@skku.edu
- 2Samsung Biomedical Research Institute, Center for Clinical Medicine, Seoul, Korea.
- 3Department of Statistics, College of Natural Science, Seoul National University, Seoul, Korea.
- 4Yong-In Mental Hospital, Yongin, Korea.
- 5Department of Psychiatry, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
Abstract
OBJECTIVES
ST8SIA2 (ST8 alpha-N-acetyl-neuraminide alpha-2, 8-sialyltransferase 2 gene) is located at 15q26, a susceptibility locus for schizophrenia. Some previous research had indicated that single-nucleotide polymorphisms (SNPs) in the promoter region of ST8SIA2 were associated with schizophrenia in Japanese and Chinese populations. We investigated the association between SNPs in the promoter region of ST8SIA2 and schizophrenia in the Korean population.
METHODS
The study subjects were 190 Korean patients with schizophrenia and 190 healthy controls. We performed allelic, genotypic, and haplotypic association analyses for rs3759916, rs3759915 and rs3759914 of ST8SIA2. All genotypes were determined by direct sequencing.
RESULTS
In the genotype-based analysis, rs3759914 showed a nominally significant association with schizophrenia under recessive genotypic model (p = 0.047). However, this association did not remain statistically significant after correction for multiple testing. Both allelic and haplotype analyses did not show any significant association.
CONCLUSIONS
These findings suggest that ST8SIA2 does not play a major role in the susceptibility to schizophrenia in the Korean population. Further studies with a larger number of subjects are required to definitively rule out minor effects of this gene on schizophrenia vulnerability.
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