Korean J Biol Psychiatry.
2012 Feb;19(1):53-57.
Association Study between DRD2 Genetic Polymorphisms and Schizophrenia in a Korean Population
- Affiliations
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- 1Department of Psychiatry, Chungnam National University Hospital, Daejeon, Korea.
- 2Department of Psychiatry, School of Medicine, Chungnam National University, Daejeon, Korea. ischee@cnu.ac.kr
- 3Department of Anatomy, School of Medicine, Chungnam National University, Daejeon, Korea.
Abstract
OBJECTIVES
This study was designed to investigate the association between the dopamine D2 receptor (DRD2) genetic polymorphism [TaqIB (rs17294542) and TaqID (rs1800498)] and patients with schizophrenia.
METHODS
TaqIB (rs17294542) and TaqID (rs1800498) polymorphism of the DRD2 gene were typed in 100 patients with schizophrenia and 109 normal controls.
RESULTS
There were no statistical differences in genotype and allele distribution of TaqIB (rs17294542) and TaqID (rs1800498) genetic polymorphism between patients with schizophrenia and normal controls.
CONCLUSIONS
These results suggest that the TaqIB (rs17294542) and TaqID (rs1800498) polymorphisms of the DRD2 gene may not be associated with schizophrenia in the Korean population.
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