J Korean Radiol Soc.  2002 Jun;46(6):561-567. 10.3348/jkrs.2002.46.6.561.

MRI after Sequential Use of Gadolinium Chelate and Mangafodipir Trisodium for the Evaluation of Focal Liver Lesions: Study of Image Findings and Safety

• Chung JJ
• Kim MJ
• Kim JH
• Lee JT
• Yoo HS

• KMID: 2024680
• DOI: http://doi.org/10.3348/jkrs.2002.46.6.561

Abstract

PURPOSE
To assess the feasibility of sequentially administering Gd-DTPA and Mn-DPDP for the MR imaging of focal hepatic lesions, and to investigate whether the procedures involved led to any adverse effects.
MATERIALS AND METHODS
Forty-two patients (M:F=25:17) with suspected hepatic lesions underwent T1-weighted MR imaging procedures before and after Gd-DTPA enhancement, and after sequential Mn-DPDP administration. Two investigators reviewed the findings in terms of the size, number, morphology, and enhancement patterns of the lesions. Any adverse actions resulting from the procedures were noted.
RESULTS
Fifteen patients had hepatocellular carcinoma (HCC, n=35), 13 showed liver metastases (n=40), nine had hemangioma (n=13), two had cholangiocarcinoma (CC, n=2), two had a liver abscess (n=2), and one had focal nodular hyperplasia (FNH, n=2). All focal hepatic lesions were clearly visible, with no difference in conspicuity between T1-weighted images obtained after Gd-DTPA administration and those obtained after Gd- DTPA plus Mn-DPDP administration. After the latter procedure, 12 HCCs showed high or iso- signal intensity to liver parenchyma and 23 showed no contrast enhancement. Thirty-eight liver metastases showed no contrast enhancement, but in two cases ring enhancement was observeed. In both cases of FNH, homogeneous enhancement was noted. No hemangiomas, CCs or abscesses demonstrated contrast enhancement. The only adverse reaction was five instances of facial flushing.
CONCLUSION
Hepatic MR imaging after sequential Gd-DTPA plus Mn-DPDP administration may be selectively useful in differentiating between hepatocellular and non-hepatocellular tumor. No technical difficulties or severe adverse reactions were encountered.

Keyword

Liver, MR; Gadolinium; Manganese; Magnetic resonance(MR), contrast enhancement

MeSH Terms

Abscess
Carcinoma, Hepatocellular
Cholangiocarcinoma
Flushing
Focal Nodular Hyperplasia
Gadolinium DTPA
Gadolinium*
Hemangioma
Humans
Liver Abscess
Liver*
Magnetic Resonance Imaging*
Manganese
Neoplasm Metastasis
Pentetic Acid
Research Personnel
Gadolinium
Gadolinium DTPA
Manganese
Pentetic Acid