J Korean Ophthalmol Soc.  1996 Jun;37(6):921-926.

The Effect of Topically Applied Sodium-hyaluronic acid(Na-HA) on Corneal Epithelial Healing

• Chung JH
• Kim EA
• Kwon KR
• Ahn CS

Abstract

To evaluate the effect of Na-hyaluronic acid (Na-HA) on corneal epithelial wound healing, twenty admitted patients (twenty-four eyes) with corneal epithelial abrasion were randomly divided into 2 groups. 1% Na-HA was given 4 times daily to 12 treated eyes while 12 control cases received antibiotic ointment therapy. Epithelial defect area was photodocumented by 6-12 hours interval and individual healing rates were calculated by linear regression analysis. The healing rate of 1% Na-HA treated cornea was 1.02 +/- 0.26mm2/hour and that of the control eyes was 0.67 +/- 0.19 mm/hour(p<0.05). The result suggests that topically applied Na-HA enhances epithelial re~surfacing when compared to the antibiotics ointment.

Keyword

Corneal epithelium; Healing rate; 1% Na-hyaluronic acid; Morphometry

MeSH Terms

Anti-Bacterial Agents
Cornea
Epithelium, Corneal
Humans
Linear Models
Wound Healing
Anti-Bacterial Agents