Korean J Obstet Gynecol.  2011 Apr;54(4):192-198. 10.5468/KJOG.2011.54.4.192.

Is the expression of p16INK4A and galectin-3 correlated with disease progression of cervical neoplasia?

• Kim SS
• Cho HY
• Kang SW
• Kim HB
• Park SH

• KMID: 2013235
• DOI: http://doi.org/10.5468/KJOG.2011.54.4.192

Abstract

OBJECTIVE
The aim of this study is to investigate whether the expressions of p16INK4A and galectin-3 are associated with the progression of cervical neoplasia and to evaluate its usefulness as a diagnostic tool.
METHODS
Eighty-seven formalin-fixed paraffin-embedded cervical specimens (20 normal, 17 LSILs, 26 HSILs, 24 invasive cervical cancers) collected between 2005 and 2009 were selected. We examined the expression of p16INK4A and galectin-3 using immunohistochemical stains with the scoring system.
RESULTS
The mean proportion of p16INK4A and galectin-3 was 0.1 and 1.70 in normal lesions, 1.35 and 2.17 in LSILs, 3.42 and 3.11 in HSILs, 3.79 and 3.08 in invasive cancers. The mean proportion of p16INK4A and galectin-3 was correlated significantly with the degree of neoplasia (P<0.05).
CONCLUSION
The increased immunohistochemical staining expressions of the p16INK4A and galectin-3 are associated with the progression of cervical neoplasia. Therefore immunohistochemical staining of p16INK4A and galectin-3 can be a useful biomarker for the diagnosis of a progression of cervical neoplasia.

Keyword

p16INK4A; Galectin-3; Uterine Cervical neoplasms; Immunohistochemistry

MeSH Terms

Coloring Agents
Disease Progression
Galectin 3
Immunohistochemistry
Uterine Cervical Neoplasms
Coloring Agents
Galectin 3

Figure

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  Fig. 1 Immunohistochemical staining of cervical neoplasia for p16INK4A (×100).

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  Fig. 2 Immunohistochemical staining of cervical neoplasia for galectin-3 (×100).

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  Fig. 3 The correlation between histologic diagnosis and immunohistochemical staining proportion. LSILs, low grade squamous intraepithelial lesions; HSILs, high grade squamous intraepithelial lesions; Ca, cancer.

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