Korean J Pathol.
2012 Dec;46(6):532-540.
Prognostic Relevance of the Expression of CA IX, GLUT-1, and VEGF in Ovarian Epithelial Cancers
- Affiliations
-
- 1Department of Pathology, Pusan National University Hospital, Pusan National University School of Medicine, Yangsan, Korea.
- 2Department of Pathology, Pusan National University School of Medicine, Yangsan, Korea. kuchoi@pusan.ac.kr
- 3Department of Pathology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.
- 4Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.
Abstract
- BACKGROUND
Tumor hypoxia is associated with malignant progression and treatment resistance. Hypoxia-related factors, such as carbonic anhydrase IX (CA IX), glucose transporter-1 (GLUT-1), and vascular endothelial growth factor (VEGF) permit tumor cell adaptation to hypoxia. We attempted to elucidate the correlation of these markers with variable clinicopathological factors and overall prognosis.
METHODS
Immunohistochemistry for CA IX, GLUT-1, and VEGF was performed on formalin-fixed, paraffin-embedded tissues from 125 cases of ovarian epithelial cancer (OEC).
RESULTS
CA IX expression was significantly associated with an endometrioid and mucinous histology, nuclear grade, tumor necrosis, and mitosis. GLUT-1 expression was associated with tumor necrosis and mitosis. VEGF expression was correlated only with disease recurrence. Expression of each marker was not significant in terms of overall survival in OECs; however, there was a significant correlation between poor overall survival rate and high coexpression of these markers.
CONCLUSIONS
The present study suggests that it is questionable whether CA IX, GLUT-1, or VEGF can be used alone as independent prognostic factors in OECs. Using at least two markers helps to predict patient outcomes in total OECs. Moreover, the inhibition of two target gene combinations might prove to be a novel anticancer therapy.
Keyword
MeSH Terms
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Anoxia
Carbonic Anhydrases
Glucose
Humans
Immunohistochemistry
Mitosis
Mucins
Necrosis
Neoplasms, Glandular and Epithelial
Ovarian Neoplasms
Recurrence
Survival Rate
Vascular Endothelial Growth Factor A
Carbonic Anhydrases
Glucose
Mucins
Neoplasms, Glandular and Epithelial
Ovarian Neoplasms
Vascular Endothelial Growth Factor A
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