J Korean Neurosurg Soc.  2004 Jan;35(1):12-16.

Clinicopathological Analysis of Subependymal Giant Cell Astocytomas in Childhood

• Kim SH
• Lee HW
• Shin HJ
• Nam DH
• Kim ES
• Eoh W

Abstract

OBJECTIVE
The authors present an evaluation of clinical features and outcome of six children with subependymal giant cell astrocytoma(SEGA). METHODS: Between 1998 and 2002, six patients aged between 6 and 15 years were diagnosed as SEGA. Five out of six children had complex signs of tuberous sclerosis(TS) and remaining one child had intraventricular tumor without the evidence of TS. We uneventfully performed complete tumor resection in all patients via transcallosal approach. One child needed ventriculoperitoneal shunt due to sustained ventriculomegaly. RESULTS: All patients remained stable and did not deteriorate neurologically compared with preoperative state at a mean follow-up of 18 months. CONCLUSION: Even though the SEGA has a benign biological behavior, surgery should be considered if there is a concurrent hydrocephalus, a sizeable tumor or interval volume increase of the tumor during the follow-up period.

Keyword

Subependymal giant cell astrocytoma; Tuberous sclerosis; Treatment outcome

MeSH Terms

Astrocytoma
Child
Follow-Up Studies
Giant Cells*
Humans
Hydrocephalus
Treatment Outcome
Tuberous Sclerosis
Ventriculoperitoneal Shunt