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Experience of a Single Center in Treating Multiple Manifestations of Tuberous Sclerosis Complex with Everolimus

Ahn H, Yum MS, Jang HN, Song C, Ko TS

PURPOSE: The aim of this study was to evaluate the efficacy and tolerability of everolimus, an oral mammalian target of rapamycin (mTOR) inhibitor, for the treatment of tuberous sclerosis complex...
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Experience Profiling of Fluorescence-Guided Surgery I: Gliomas

Ji SY, Kim JW, Park CK

BACKGROUND: Numerous studies reported a usefulness of 5-aminolevulinic acid (5-ALA) fluorescence-guided surgery (FGS) in high grade gliomas. However, fluorescence patterns and intensities are variable among gliomas. In this study, we...
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Survival and Prognosis of Patients with Pilocytic Astrocytoma: A Single-Center Study

Park JH, Jung N, Kang SJ, Kim HS, Kim E, Lee HJ, Jung HR, Choe M, Shim YJ

BACKGROUND: Pilocytic astrocytoma (PA) is a brain tumor that is relatively more common in children and young adults. METHODS: We retrospectively reviewed the medical records of patients with PA treated at...
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The Korean Society for Neuro-Oncology (KSNO) Guideline for WHO Grade II Cerebral Gliomas in Adults: Version 2019.01

Kim YZ, Kim CY, Wee CW, Roh TH, Hong JB, Oh HJ, Kang SG, Kang SH, Kong DS, Kim SH, Kim SH, Kim SH, Kim YJ, Kim EH, Kim IA, Kim HS, Park JS, Park HJ, Song SW, Sung KS, Yang SH, Yoon WS, Yoon HI, Lee J, Lee ST, Lee SW, Lee YS, Lim J, Chang JH, Jung TY, Jung HL, Cho JH, Choi SH, Choi HS, Lim DH, Chung DS, KSNO Guideline Working Group

BACKGROUND: There was no practical guideline for the management of patients with central nervous system tumor in Korea for many years. Thus, the Korean Society for Neuro-Oncology (KSNO), a multidisciplinary...
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The Korean Society for Neuro-Oncology (KSNO) Guideline for WHO Grade III Cerebral Gliomas in Adults: Version 2019.01

Kim YZ, Kim CY, Lim J, Sung KS, Lee J, Oh HJ, Kang SG, Kang SH, Kong DS, Kim SH, Kim SH, Kim SH, Kim YJ, Kim EH, Kim IA, Kim HS, Roh TH, Park JS, Park HJ, Song SW, Yang SH, Yoon WS, Yoon HI, Lee ST, Lee SW, Lee YS, Wee CW, Chang JH, Jung TY, Jung HL, Cho JH, Choi SH, Choi HS, Hong JB, Lim DH, Chung DS, KSNO Guideline Working Group

BACKGROUND: There was no practical guideline for the management of patients with central nervous system tumor in Korea in the past. Thus, the Korean Society for Neuro-Oncology (KSNO), a multidisciplinary...
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Reclassification of Mongolian Diffuse Gliomas According to the Revised 2016 World Health Organization Central Nervous System Tumor Classification

Ochirjav E, Enkhbat B, Baldandorj T, Choe G

BACKGROUND: The 2016 World Health Organization (WHO) classification of central nervous system (CNS) tumors has been modified to incorporate the IDH mutation and 1p/19q co-deletion in the diagnosis of diffuse...
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Clinical Pearls and Advances in Molecular Researches of Epilepsy-Associated Tumors

Phi JH, Kim SK

Brain tumors are the second most common type of structural brain lesion that causes chronic epilepsy. Patients with low-grade brain tumors often experience chronic drug-resistant epilepsy starting in childhood, which...
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A Case of Recurrent Supratentorial Extraventricular Anaplastic Ependymoma in Adult

Seo SW, Kang HJ, Lee MS, Suh SJ, Lee YS, Lee JH, Kang DG

Supratentorial extraventricular anaplastic ependymoma (SEAE) in adults is a relatively rare intracranial tumor. Because of the very low prevalence, only a few cases have been reported. According to a recent...
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Tuberous Sclerosis Complex with Crohn's Disease

Kim MH, Lee YJ, Kim JY, Yi YY, Kang JW

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutation of one of two genes, TSC1 (encoding hamartin, 9q34) and TSC2 (encoding tuberin, 16p13). It invades the central...
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Efficacy of Gamma Knife Radiosurgery for Recurrent High-Grade Gliomas with Limited Tumor Volume

Cheon YJ, Jung TY, Jung S, Kim IY, Moon KS, Lim SH

OBJECTIVE: This study aims to determine whether gamma knife radiosurgery (GKR) improves survival in patients with recurrent highgrade gliomas. METHODS: Twenty nine patients with recurrent high-grade glioma underwent 38 GKR. The...
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Effect of Necrosis on the miRNA-mRNA Regulatory Network in CRT-MG Human Astroglioma Cells

Ahn SH, Ahn JH, Ryu DR, Lee J, Cho MS, Choi YH

PURPOSE: Glioblastoma multiforme (GBM) is the most common adult primary intracranial tumor. The remarkable features of GBM include central necrosis. MicroRNAs (miRNAs) have been considered as diagnostic/prognostic biomarkers for many...
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Intermediate Pilomyxoid Astrocytoma in the Cerebellum of a 5-Year-Old Boy

Kil JS, Lee KH, Eom KS, Kim TY

Intermediate pilomyxoid tumors (IPTs) were defined by the presence of some features typical of pilomyxoid astrocytoma (PMA) in combination with features that could be considered more consistent with pilocytic astrocytoma...
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Spinal Cord Subependymoma Surgery: A Multi-Institutional Experience

Yuh WT, Chung CK, Park SH, Kim KJ, Lee SH, Kim KT

OBJECTIVE: A spinal cord subependymoma is an uncommon, indolent, benign spinal cord tumor. It is radiologically similar to a spinal cord ependymoma, but surgical findings and outcomes differ. Gross total...
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Reclassification of Mixed Oligoastrocytic Tumors Using a Genetically Integrated Diagnostic Approach

Kim SI, Lee Y, Won JK, Park CK, Choi SH, Park SH

BACKGROUND: Mixed gliomas, such as oligoastrocytomas (OA), anaplastic oligoastrocytomas, and glioblastomas (GBMs) with an oligodendroglial component (GBMO) are defined as tumors composed of a mixture of two distinct neoplastic cell...
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Hearing Preservation with the Transcrusal Approach to the Skull Base Lesion Combined with Other Transcranial Approach: Results of Consecutive Series of 5 Cases

Lee SM, Ko BJ, Sung HK, Kim HK, Hong JB, An YS

BACKGROUND AND OBJECTIVES: This study reviewed our experience and outcomes of surgery via transcrusal approach to the skull base lesions. SUBJECTS AND METHOD: We performed transcrusal approach technique on five patients...
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Supratentorial Pilocytic Astrocytoma Mimicking Convexity Meningioma with Early Anaplastic Transformation: A Case Report

Lee JH, Sung SK, Choi CH

Meningiomas and pilocytic astrocytomas are benign intracranial tumors. Pilocytic astrocytomas arises frequently at the posterior fossa in childhood. Meningiomas have several image findings, such as a dural tail sign, bony...
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Isolated Trochlear Palsy Due to Pilocytic Astrocytoma Involving the Pineal Gland

Lim SH, Lee ES, Choi JY, Kim JS

No abstract available.
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Effect of glucose level on chemical hypoxia- and hydrogen peroxide-induced chemokine expression in human glioblastoma cell lines

Jung Y, Ahn SH, Park SH, Choi YH

Glioblastoma multiforme (GBM) is the most common primary intracranial tumor in adults and has poor prognosis. The GBM-specific tumor microenvironment (TME) plays a crucial role in tumor progression, immune escape,...
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Molecular Testing of Brain Tumor

Park SH, Won J, Kim SI, Lee Y, Park CK, Kim SK, Choi SH

The World Health Organization (WHO) classification of central nervous system (CNS) tumors was revised in 2016 with a basis on the integrated diagnosis of molecular genetics. We herein provide the...
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Endoscopic Treatment of an Adult with Tegmental Astrocytoma Accompanied by Cerebrospinal Fluid Dissemination

Lu R, Li C, Wang X, Zhang Y

Midbrain gliomas are relatively rare neoplasms with a generally benign prognosis, with dissemination or metastasis not previously reported. We describe here a woman, in whom magnetic resonance imaging scans showed...
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