J Korean Breast Cancer Soc.  2003 Jun;6(2):95-102. 10.4048/jkbcs.2003.6.2.95.

Neoadjuvant Chemotherapy Decreases the Identification Rate of Sentinel Lymph Node Biopsy

• Kang SH
• Lee ES
• Kang HS
• Ro JS
• Lee S
• Kang KW

• KMID: 2006613
• DOI: http://doi.org/10.4048/jkbcs.2003.6.2.95

Abstract

PURPOSE
We investigated the feasibility and clinical applicability of sentinel lymph node biopsy (SLNB) in patients with neoadjuvant chemotherapy, tumor size > 2 cm, and privious excisional biopsy. METHODS: 175 patients with 176 breast cancer underwent aLNB between October 2001 and October 2002. Among them twenty-five patients with locally advanced breast cancer underwent SLNB after neoadjuvant chemotherapy. Eighty-nine (50.6%) had primary tumor > 2 cm. The recent biopsy method used before SLNB was excision in thirty-one (17.6%) procedures. The identification rate, false-negative rate, negative prediction value and accuracy of SLNB were determined. RESULTS: SLNB was successful in 164 of 176 cases (detection rate, 93.2%). The identification rate of patients who had neoadjuvant chemotherapy was 68% and lower than that of who had not (97.3%), significantly (P=0.00). However, mapping success was not influenced by large tumor size (> 2 cm) or previous excisional biopsy. The false-negative rate and accuracy were 16.5% and 91.5, respectively. The false negative rate was 21.3% (3/14) in those patients received neoadjuvant chemotherapy compared with a 15.5% in those patents not received neoadjuvant chemotherapy (P> 0.05). In addition, Tumor size > 2 cm and previous excision did not adversely impact the false negative rate and accuracy. CONCLUSION: Neoadjuvant chemotherapy was associated with a lower identification rate for SLNB. But if detected, SLNB after neoadjuvant chemotherapy might reliably predict axillary status. SLNB is feasible and accurate in patients with large tumor (> 2 cm) and previous excision.

Keyword

Breast cancer; Excisional biopsy; Neoadjuvant chemotherapy; Sentinel lymph node biopsy; Tumor size

MeSH Terms

Biopsy
Breast Neoplasms
Drug Therapy*
Humans
Sentinel Lymph Node Biopsy*