J Lipid Atheroscler.  2015 Jun;4(1):17-25. 10.12997/jla.2015.4.1.17.

Consumption of Added Sugars and Lipid Profiles in Korean Population from a Cohort Study

• Kim SY
• Jee SH

• KMID: 2005731
• DOI: http://doi.org/10.12997/jla.2015.4.1.17

Abstract

OBJECTIVES
The purpose of the study was to examine the relationship between added sugar consumption and dyslipidemia.
METHODS
Final study subjects consisted of 18,713 participants after the exclusion of participants with dyslipidemia or under lipid lowering medications at baseline. Added sugar levels were categorized into tertiles [men: Low <8.0 g, Middle: 8.0-21.9 g, High > or =22.0 g; women: Low <6.0 g, Middle 6.0-14.9 g, High > or =15.0 g]. Dyslipidemia was analyzed based on two of the most recent guidelines identified from the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and the 2009 Korean Society of Lipidology and Atherosclerosis (KSLA). We used Kaplan-Meier and Cox proportional hazard models to estimate the hazard ratio (HR) with 95% confidence interval (CI) of dyslipidemia.
RESULTS
High added sugar was associated with hypercholesteremia (HR, 1.22; 95% CI, 1.06-1.40), high LDL cholesterolemia (1.29; 1.13-1.48), and low HDL cholesterolemia (1.26; 1.10-1.44) based on the KSLA Standard in men. In women, the high added sugar was only related to the risk for hypercholesteremia (1.26; 1.07-1.49) based on the KSLA Standard. A similar trend was shown in both men and women with application of NCEP-ATP III standard.
CONCLUSION
In this study, an increase in added sugar consumption was associated with an increased risk of dyslipidemia in men. Additional studies assessing the association between cardiovascular and other diseases should be conducted in the future.

Keyword

Added sugar; Lipid profiles; Dyslipidemia; Cohort study

MeSH Terms

Adenosine Triphosphate
Adult
Atherosclerosis
Carbohydrates*
Cholesterol
Cohort Studies*
Dyslipidemias
Education
Female
Humans
Hypercholesterolemia
Male
Proportional Hazards Models
Adenosine Triphosphate
Carbohydrates
Cholesterol

Figure

• 

  Fig. 1 Distribution of dyslipidemia incidence according to added sugar consumptions and medical treatment guidance in men. Added sugars (g/day); T1 (<8.0), T2 (8.0-21.9), T3 (≥22.0), LDL; Low density Lipoprotein, HDL; High density Lipoprotein, TG; Triglyceride, S(t); Cum survival

• 

  Fig. 2 Distribution of Elevated TG/HDL cholesterol ratio incidence according to added sugar consumptions in men. Added sugars (g/day): T1 (<8.0), T2 (8.0-21.9), T3 (≥22.0), HDL; High density Lipoprotein, TG; Triglyceride, S(t); Cum survival

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