J Lipid Atheroscler.
2022 Jan;11(1):20-38. 10.12997/jla.2022.11.1.20.
Metabolism and Health Impacts of Dietary Sugars
- Affiliations
-
- 1Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA
- 2Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, USA
- 3Center for Complex Biological Systems, University of California Irvine, Irvine, CA, USA
- 4Center for Epigenetics and Metabolism, University of California Irvine, Irvine, CA, USA
- KMID: 2525231
- DOI: http://doi.org/10.12997/jla.2022.11.1.20
Abstract
- Consumption of excessive amounts of added sugars and their effects on human health has been a major concern in the last several decades. Epidemiological data suggest that the incidence of metabolic disorders, such as obesity, nonalcoholic fatty liver disease, cardiovascular disease and diabetes, has increased due to chronic surplus consumption of these sugars. While many of these sugars have been isolated and studied for centuries, their health impacts and exact underlying mechanisms are still unclear. In this review, we discuss the pathophysiological role of 6 major simple sugars present in the human diet and the biochemical and molecular pathways related to their metabolism by different organs and gut microbiota, with a focus on the most recent investigations.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Ultra-processed foods and total sugars intake in Korea: evidence from the Korea National Health and Nutrition Examination Survey 2016–2018
- The Sugars Intake through Processed Foods and Its Related Factors in College Students
- Status and needs of nutrition education for children's sugars intake reduction in elementary school
- Development of a Food Exchange Table and Food Pattern for Nutritionally Balanced Menu Planning
- Assessment of the Sugars Contents in Home Meal Replacement Products Sold in Korea
