J Korean Assoc Oral Maxillofac Surg.  2014 Oct;40(5):220-224. 10.5125/jkaoms.2014.40.5.220.

Assessment of interleukin-1beta and interleukin-6 in the crevicular fluid around healthy implants, implants with peri-implantitis, and healthy teeth: a cross-sectional study

• Yaghobee S
• Khorsand A
• Rasouli Ghohroudi AA
• Sanjari K
• Kadkhodazadeh M

• KMID: 2005451
• DOI: http://doi.org/10.5125/jkaoms.2014.40.5.220

Abstract

OBJECTIVES
This study aimed to assess and compare the levels of interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in the crevicular fluid around healthy implants, implants with peri-implantitis, and healthy teeth.
MATERIALS AND METHODS
This study evaluated 16 dental implants in 8 patients (4 males and 4 females). These patients had at least one healthy implant and one implant with peri-implantitis next to healthy teeth. The crevicular fluid was collected using absorbent cones and transferred to the laboratory. Specimens were evaluated by ELISA for interleukin levels. Data were analyzed using repeated measures ANOVA and Bonferroni tests (P<0.05).
RESULTS
Levels of IL-1beta in the crevicular fluid around implants with peri-implantitis were significantly higher than around healthy implants (P=0.002); the latter was significantly higher than around healthy teeth (P=0.015). A significant difference was found in the level of IL-6 in the crevicular fluid around implants with peri-implantitis and healthy implants (P=0.049) and also between implants with peri-implantitis and healthy teeth (P<0.001).
CONCLUSION
Within the limitations of this study, significant differences exist in the levels of IL-1beta and IL-6 in the crevicular fluid of implants with peri-implantitis, healthy implants, and healthy teeth. More studies with larger sample sizes in different populations are necessary.

Keyword

Dental implants; Peri-implantitis; Interleukin-1beta; Interleukin-6; Gingival crevicular fluid

MeSH Terms

Cross-Sectional Studies*
Dental Implants
Enzyme-Linked Immunosorbent Assay
Gingival Crevicular Fluid
Humans
Interleukin-1beta*
Interleukin-6*
Interleukins
Male
Peri-Implantitis*
Sample Size
Tooth*
Dental Implants
Interleukin-1beta
Interleukin-6
Interleukins