- Interleukin 1β Up-Regulates mRNA Expression of Inducible Nitric Oxide Synthase in 3T3-L1 Preadipocytes: Role of JAKs/STATs, PKCs, and Src
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Park YK, Wang S, Jang BC
- KMID: 2516703
- Keimyung Med J.
- 2021 Jun;40(1):1-8.
- doi: 10.46308/kmj.2021.00108
Recent evidence suggests obesity as a low or systemic chronic inflammation. (Pre)adipocytes in the adipose tissue (AT) express and secrete a variety of cytokines and adipokines. Inducible nitric oxide synthase... -
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- Gemigliptin Inhibits Interleukin-1β–Induced Endothelial-Mesenchymal Transition via Canonical-Bone Morphogenetic Protein Pathway
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Hong OK, Lee SS, Yoo SJ, Lee MK, Kim MK, Baek KH, Song KH, Kwon HS
- KMID: 2503269
- Endocrinol Metab.
- 2020 Jun;35(2):384-395.
- doi: 10.3803/EnM.2020.35.2.384
Background: Endothelial-to-mesenchymal transition (EndMT) contributes to inflammatory conditions inducing conversion of endothelial cells (ECs) into activated fibroblasts, promoting fibrotic diseases. Pro-inflammatory cytokine is the most potent inducer of EndMT. We... -
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- The Correlation between IL-1β-C31T Gene Polymorphism and Susceptibility to Breast Cancer
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Eras N, Daloglu FT, Çolak T, Guler M, Akbas E
- KMID: 2450116
- J Breast Cancer.
- 2019 Jun;22(2):210-218.
- doi: 10.4048/jbc.2019.22.e27
PURPOSE: Interleukin-1 beta (IL-1β), a pro-inflammatory cytokine, has been shown to influence breast cancer susceptibility. The relationship between its risk of breast cancer and IL-1β-C31T polymorphism has been demonstrated, but... -
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- Expression of Fibroblast Growth Factor 21 and β-Klotho Regulates Hepatic Fibrosis through the Nuclear Factor-κB and c-Jun N-Terminal Kinase Pathways
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Lee KJ, Jang YO, Cha SK, Kim MY, Park KS, Eom YW, Baik SK
- KMID: 2417312
- Gut Liver.
- 2018 Jul;12(4):449-456.
- doi: 10.5009/gnl17443
BACKGROUND/AIMS: Fibroblast growth factor (FGF) 21 is associated with hepatic inflammation and fibrosis. However, little is known regarding the effects of inflammation and fibrosis on the β-Klotho and FGF21 pathway... -
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- The Allele 2 of the VNTR Polymorphism in the Gene That Encodes a Natural Inhibitor of IL-1β, IL-1RA Is Favorably Associated With Chronic Otitis Media
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Živković M, Kolić I, Jesić S, Jotić A, Stanković A
- KMID: 2412669
- Clin Exp Otorhinolaryngol.
- 2018 Jun;11(2):118-123.
- doi: 10.21053/ceo.2017.01060
OBJECTIVES: Chronic otitis media (COM) is followed by irreversible tissue damage and destruction of the middle ear structures, with the possibility of complications under the maintenance of inflammation. Inflammatory mediators... -
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- Porcine circovirus type 2 increases interleukin-1beta and interleukin-10 production via the MyD88–NF-kappa B signaling pathway in porcine alveolar macrophages in vitro
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Han J, Zhang S, Zhang Y, Chen M, Lv Y
- KMID: 2412571
- J Vet Sci.
- 2017 Jun;18(2):183-191.
- doi: 10.4142/jvs.2017.18.2.183
Porcine alveolar macrophages (PAMs) represent the first line of defense in the porcine lung after infection with porcine circovirus type 2 (PCV2) via the respiratory tract. However, PCV2 infection impairs... -
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- Serum interleukin-1beta and tumor necrosis factor-alpha in febrile seizures: is there a link?
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Mahyar A, Ayazi P, Orangpour , Daneshi-Kohan MM, Sarokhani , Javadi A, Habibi M, Talebi-Bakhshayesh M
- KMID: 2284383
- Korean J Pediatr.
- 2014 Oct;57(10):440-444.
- doi: 10.3345/kjp.2014.57.10.440
PURPOSE: Febrile seizures are induced by fever and are the most common type of seizures in children. Although numerous studies have been performed on febrile seizures, their pathophysiology remains unclear.... -
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- Assessment of interleukin-1beta and interleukin-6 in the crevicular fluid around healthy implants, implants with peri-implantitis, and healthy teeth: a cross-sectional study
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Yaghobee S, Khorsand A, Rasouli Ghohroudi AA, Sanjari K, Kadkhodazadeh M
- KMID: 2005451
- J Korean Assoc Oral Maxillofac Surg.
- 2014 Oct;40(5):220-224.
- doi: 10.5125/jkaoms.2014.40.5.220
OBJECTIVES: This study aimed to assess and compare the levels of interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in the crevicular fluid around healthy implants, implants with peri-implantitis, and healthy teeth. MATERIALS AND... -
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- Dexamethasone Inhibits Interleukin-1beta-Induced Matrix Metalloproteinase-9 Expression in Cochlear Cells
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Nam SI, Kwon TK
- KMID: 1973466
- Clin Exp Otorhinolaryngol.
- 2014 Sep;7(3):175-180.
- doi: 10.3342/ceo.2014.7.3.175
OBJECTIVES: To investigate the effect of interleukin (IL)-1beta on matrix metalloproteinase (MMP)-9 expression in cochlea and regulation of IL-1beta-mediated MMP-9 expression by dexamethasone and the molecular and signaling mechanisms involved. METHODS:... -
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- Evaluation of interleukin-1beta and 8 in gutka chewers with periodontitis among a rural Indian population
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Jacob PS, Nath S, Patel RP
- KMID: 2012987
- J Periodontal Implant Sci.
- 2014 Jun;44(3):126-133.
- doi: 10.5051/jpis.2014.44.3.126
PURPOSE: Smokeless tobacco-based oral-use products like gutka are popular in India. Gutka usage leads to increased periodontal destruction and inflammation; however, the relevant mechanism remains unknown. This study aimed to... -
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- Clinical Implications of VEGF, TGF-beta1, and IL-1beta in Patients with Advanced Non-small Cell Lung Cancer
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Kim JW, Koh Y, Kim DW, Ahn YO, Kim TM, Han SW, Oh DY, Lee SH, Im SA, Kim TY, Heo DS, Bang YJ
- KMID: 2167643
- Cancer Res Treat.
- 2013 Dec;45(4):325-333.
PURPOSE: Vascular endothelial growth factor (VEGF)-A, VEGF165b, interleukin (IL)-1beta, and transforming growth factor (TGF)-beta1 are known to influence tumor angiogenesis. Clinical implications of these cytokines need to be elucidated. MATERIALS AND... -
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- Inflammasomes, multi-cellular protein complex in myeloid cells, induce several metabolic diseases via interleukin-1beta maturation
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Lee GS
- KMID: 1703511
- J Biomed Res.
- 2013 Dec;14(4):195-200.
Inflammation mainly mediated by innate immune cells as the first line of host defense against pathogens is an acute response that limits tissue damage and eliminates pathogens in the body.... -
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- Prostaglandin E2 and Interleukin-1beta Reduce E-cadherin Expression by Enhancing Snail Expression in Gastric Cancer Cells
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Jee YS, Jang TJ, Jung KH
- KMID: 1782129
- J Korean Med Sci.
- 2012 Sep;27(9):987-992.
- doi: 10.3346/jkms.2012.27.9.987
Inflammation is closely related to the progression of cancer as well as tumorigenesis. Here, we investigated the effect of prostaglandin E2 (PGE2) and interleukin-1beta (IL-1beta) on E-cadherin expression in SNU719... -
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- Synergy between adiponectin and interleukin-1beta on the expression of interleukin-6, interleukin-8, and cyclooxygenase-2 in fibroblast-like synoviocytes
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Lee YA, Choi HM, Lee SH, Yang HI, Yoo MC, Hong SJ, Kim KS
- KMID: 1397448
- Exp Mol Med.
- 2012 Jul;44(7):440-447.
To determine whether adiponectin may have synergistic effects in combination with the proinflammatory cytokine interleukin (IL)-1beta regarding the production of proinflammatory mediators during arthritic joint inflammation, synovial cells from rheumatoid... -
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- Effect of manassantin B, a lignan isolated from Saururus chinensis, on lipopolysaccharide-induced interleukin-1beta in RAW 264.7 cells
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Park HC, Bae HB, Jeong CW, Lee SH, Jeung HJ, Kwak SH
- KMID: 2236296
- Korean J Anesthesiol.
- 2012 Feb;62(2):161-165.
- doi: 10.4097/kjae.2012.62.2.161
BACKGROUND: Elevated systemic levels of pro-inflammatory cytokines cause hypotension during septic shock and induce capillary leakage in acute lung injury. Manassantin B has anti-inflammatory and anti-plasmoidal properties. This study examined... -
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- Rottlerin enhances IL-1beta-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells
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Park EJ, Kwon TK
- KMID: 1058704
- Exp Mol Med.
- 2011 Dec;43(12):669-675.
- doi: 10.3858/emm.2011.43.12.077
Cyclooxygenase-2 (COX-2) is an important enzyme in inflammation. In this study, we investigated the underlying molecular mechanism of the synergistic effect of rottlerin on interleukin1beta (IL-1beta)-induced COX-2 expression in MDA-MB-231... -
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- Grape seed proanthocyanidin extract ameliorates monosodium iodoacetate-induced osteoarthritis
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Woo YJ, Joo YB, Jung YO, Ju JH, Cho ML, Oh HJ, Jhun JY, Park MK, Park JS, Kang CM, Sung MS, Park SH, Kim HY, Min JK
- KMID: 1123368
- Exp Mol Med.
- 2011 Oct;43(10):561-570.
- doi: 10.3858/emm.2011.43.10.062
Osteoarthritis (OA) is an age-related joint disease that is characterized by degeneration of articular cartilage and chronic pain. Oxidative stress is considered one of the pathophysiological factors in the progression... -
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- Interleukin-1beta, Calcium-Sensing Receptor, and Urokinase Gene Polymorphisms in Korean Patients with Urolithiasis
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Kim JY, Kim YS, Jang IH, Jung JD, Kim TH, Kim HR
- KMID: 2315522
- Korean J Urol.
- 2011 May;52(5):340-344.
PURPOSE: There are various causes of ureter calculi, and genetic factors are known to play a role. Interleukin-1beta (IL-1beta) and calcium-sensing receptor (CaSR) genes are related to hypercalciuria, and urokinase... -
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- Analysis of Cytokines in Sera from Type 1 Diabetic Patients at Diagnosis
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Yoon IS, Shin CH, Yang SW
- KMID: 1450618
- J Korean Soc Pediatr Endocrinol.
- 2011 Apr;16(1):13-19.
- doi: 10.6065/jkspe.2011.16.1.13
PURPOSE: Diverse cytokines influence the pathogenesis of type 1 diabetes mellitus (T1DM) in different ways. We studied the profile of cytokines in sera from type 1 diabetic patients at diagnosis. METHODS:... -
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- Evaluation of osteogenic activity of periosteal-derived cells treated with inflammatory cytokines
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Park BW, Choi MJ, Hah YS, Cho HY, Kim DR, Kim UK, Kang HJ, Kim JR, Byun JH
- KMID: 2328497
- J Korean Assoc Oral Maxillofac Surg.
- 2010 Oct;36(5):341-345.
INTRODUCTION: Skeletal homeostasis is normally maintained by the stability between bone formation by osteoblasts and bone resorption by osteoclasts. However, the correlation between the inflammatory reaction and osteoblastic differentiation of... -
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