J Korean Assoc Oral Maxillofac Surg.
2007 Oct;33(5):548-553.
Oral squamous cell carcinoma associated with human papillomavirus infections; two cases report and review of the literature
- Affiliations
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- 1Department of Oral & Maxillofacial Surgery, School of Medicine and Institute of Health Sciences, Gyeongsang National University, Korea. parkbw@gsnu.ac.kr
- 2Department of Pathology, School of Medicine, Gyeongsang National University, Korea.
- 3Department of Theriogenology & Biotechnology, College of Veterinary Medicine, Gyeongsang National University, Korea.
- 4Department of Oral & Maxillofacial Surgery, School of Dentistry, Pusan National University, Korea.
Abstract
- Several investigators have shown that human papillomavirus (HPV) appear to play an etiologic role in oral and paranasal sinus carcinoma. It was known that 15-25 % of head and neck squamous cell carcinoma (SCC) showed HPV-positive infection. Among them, HPV 16 was the most common type but HPV 18 was observed only 2-4 % of HPV-positive head and neck cancers. In recent, we treated uncommon 2 oral SCC cases that associated with HPV infection. One is a case of tongue SCC after bone marrow transplantation (BMT), and the other is a case of SCC occurring with aspergillosis in the maxillary sinus. After surgery, HPV 16 and 18 were detected in the surgical specimens by the histological and polymerase chain reaction (PCR) examination. In this report, we present these cases with a review of literature.
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