J Korean Assoc Maxillofac Plast Reconstr Surg.  2007 Nov;29(6):548-553.

A Case report of Kikuchi-Fujimoto Disease

• Jang TH
• Kim JW
• Kwon TG
• Jang HJ
• Kim CS
• Lee SH

Abstract

Kikuchi-Fujimoto disease is a rare disease first described in 1972 by Kikuchi and Fujimoto et al. The disease is described as a benign and unusual self-limiting histiocytic necrotizing lymphadenitis of unknown origin, which is characterized histologically by necrotic foci surrounded by histiocytic aggregates, is usually manifested with lymphadenopathy and high fever. This disease mostly affects young Asian women between 20 and 30 years of age and has rarely been reported in children. Main symptoms are indolent or light tender, enlarged lymph nodes in the neck area. The correct diagnosis requires the histologic examination of the lymph node. Kikuchi-Fujimoto disease is easily confused histologically and clinically with lymphoma and systemic lupus erythematosis histologically and clinically. Although it is an uncommon cause of fever of unknown origin, early recognition of KFD is very important and will minimize potentially harmful and unnecessary evaluations and treatments. We reported a case, a 23-year old man who had Kikuchi-Fujimoto disease with a literature review.

Keyword

Kikuchi; Fujimoto; Necrotizing lymphadenitis; Karyorrhexis; Fever

MeSH Terms

Asian Continental Ancestry Group
Child
Diagnosis
Female
Fever
Fever of Unknown Origin
Histiocytic Necrotizing Lymphadenitis*
Humans
Lymph Nodes
Lymphatic Diseases
Lymphoma
Neck
Rare Diseases
Young Adult