J Korean Androl Soc.  1996 Jun;14(1):21-25.

Incidence of Hyperlipidemia in Vasculogenic Impotence

• Lee SK
• Kim SC

Abstract

It has been suggested that hyperlipidemia contributes to vasculogenic impotence by atherosclerosis-induced intraluminal occlusion, impairment of endothelium-dependent relaxation of cavernosal smooth muscle, or degeneration of the smooth muscle. To investigate the incidence of hyperlipidemia in the population with vasculogenic impotence, 580 patients with this disorder and 95 normally potent men aged 40 to 69 years were studied. The serum concentrations of total cholesterol (TCh), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), lipoprotein (LP) a, apoprotein (Apo) A1, ApoB, and Phospholipid (PL) were measured. Also, we determined whether any of the relations reported to be possible risk factors of atherosclerosis, namely LDL/HDL >3.3,B TCh/HDL >4.7, ApoA1/ApoB >1.3, high TG-low HDL, high TG-high ApoA1, high TG-high ApoB, or high TCh-high TG, were present. The incidence of abnormally high individual lipid fractions and abnormal ratios were then compared in the vasculogenically impotent and potent men by statistical analysis using ANOVA and chi-square tests. Significant differences in the incidence of abnormally high serum lipid concentrations were found only for TCh (p=0.008) and LPa (p=0.019). There was no significant difference between the two groups in any of the ratios. Hypercholesterolemia seems to be the greatest risk factor among the lipid fractions in the pathogenesis of vasulogenic impotence.

MeSH Terms

Apolipoproteins B
Apoproteins
Atherosclerosis
Cholesterol
Erectile Dysfunction
Female
Humans
Hypercholesterolemia
Hyperlipidemias*
Impotence, Vasculogenic*
Incidence*
Lipoproteins
Male
Muscle, Smooth
Relaxation
Risk Factors
Triglycerides
Apolipoproteins B
Apoproteins
Cholesterol
Lipoproteins