Korean J Urol.  1994 Oct;35(10):1113-1121.

Hyperlipidemia and Erection Response by Intracorporeal Injection of Papaverine

• Ko YT
• Kim SC

Abstract

The majority of cases of impotence are closely associated with vascular risk factors and previous studies suggested that hypercholesterolemia contributed to the vasculogenic impotence by inducing impairment of endothelium dependent relaxation of corporeal smooth muscles. However, the roles of individual parameters of lipid metabolism in the development of the vasculogenic impotence are ill defined. Herein we investigated the relationship between the erectile response induced by intracorporeal injection of papaverine and serum levels of various parameters of lipid metabolism ; total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), lipoprotein(a). phospholipid, apoprotein A1(ApoA1), apoprotein B(ApoB), and ratio of serum level of LDL/HDL, TC/HDL, and ApoA1/ApoB. Higher incidence of abnormal erectile response was found in patients with increased serum level of TC, LDL, ApoA1, phospholipid and increased LDL/HDL ratio, However, the erectile response to intracorporeal papaverine between the patients with abnormal parameters and those with normal levels did not show significant difference(p>0.15). These results suggest that the individual parameters of lipid metabolism by themselves may not have direct relationship with papaverine induced erectile response.

Keyword

Hyperlipidemia; Erection response; Papaverine

MeSH Terms

Apoproteins
Cholesterol
Endothelium
Erectile Dysfunction
Female
Humans
Hypercholesterolemia
Hyperlipidemias*
Impotence, Vasculogenic
Incidence
Lipid Metabolism
Lipoprotein(a)
Lipoproteins
Male
Muscle, Smooth
Papaverine*
Relaxation
Risk Factors
Triglycerides
Apoproteins
Cholesterol
Lipoprotein(a)
Lipoproteins
Papaverine