J Korean Soc Transplant.  2006 Jun;20(1):99-103.

Treatment of Acute and Chronic Wound in Immunodeficiency Patients Using Easyef(R) (EGF)

• Cho JH
• Lew DH
• Kim YS
• Tark KC

Abstract

PURPOSE: The mechanism of wound healing is a complex process which includes coagulation, inflammation, fibroplasia and scar remodeling phase. Various factors, such as immune status of host, growth factors and many enzymes play significant roles in wound healing process. Especially those who are immunosuppressed have reduced humoral immunity leading to blockade in inflammatory phase and decreased secrection of various growth factors, resulting in delayed wound healing. We tried to accelerate the wound healing process in the immunosuppressed patients by introducing the exogenous growth factors.
METHODS AND RESULTS
From March 2004 to February 2005, ten patients who were administered with immunosuppressant medications or had undergone long-term immuno-deficit state were treated with EGF. Patients had an average of 9 x 6 cm skin defect due to either trauma or infection, and with good wound care and twice-a-day application of Easyef(R)(human recombinant epidermal growth factor, Dae-Woong), complete healing was achieved in all wounds in an average of 3 months.
CONCLUSION
The treatment of wound with application of epidermal growth factor can be a method of choice in treating wounds in the immunosuppressed patients.

Keyword

Growth factor; Wound healing; Immunodeficiency patient

MeSH Terms

Cicatrix
Epidermal Growth Factor
Humans
Immunity, Humoral
Inflammation
Intercellular Signaling Peptides and Proteins
Skin
Wound Healing
Wounds and Injuries*
Epidermal Growth Factor
Intercellular Signaling Peptides and Proteins