J Wound Manag Res.  2023 Feb;19(1):38-45. 10.22467/jwmr.2022.02187.

Treatment of Partial-Thickness Burn Wounds with Combined Advanced Therapies: Cultured Allogenic Keratinocyte and Epidermal Growth Factor

• Lee KD
• Cha EC
• Lee J
• Kang SY
• Burm JS
• Cho J

• KMID: 2540017
• DOI: http://doi.org/10.22467/jwmr.2022.02187

Abstract

Background
Cultured allogenic keratinocyte (CAK) and epidermal growth factor (EGF) are commonly used biological treatments for partial-thickness burn wounds. A comparative study was conducted on whether the combination therapy of CAK and EGF promotes partial-thickness burn wound healing.
Methods
From January 2020 to March 2021, 73 patients who visited the hospital with partial-thickness burns were enrolled in the study. Patients were treated with CAK (Kaloderm) (n=20), EGF (Easyef) (n=17), and CAK+EGF (n=24). Wound healing rate, time to heal, factors affecting wound healing (age, sex, underlying disease, mode of injury, location of injury, initial wound size), and scarring were comparatively analyzed.
Results
The wound healing rate for 20 days was 85% (17/20) in the CAK group, 88% (15/17) in the EGF group, and 92% (22/24) in the CAK+EGF group. The average healing time was 11.0±6.0 days, with the CAK group taking 12.6±5.5 days, EGF group taking 11.5±6.0 days, and CAK+EGF group taking 9.0±6.3 days. The patients who received CAK+EGF treatment had higher hazard than the patients without CAK+EGF treatment (hazard ratio, 2.078; 95% confidence interval, 1.021–4.228). Smaller wound size <5 cm2 (hazard ratio, 2.869; 95% confidence interval, 1.426–5.773) was associated with complete wound healing. Though statistically insignificant (P=0.218), less scars occurred in the CAK+EGF group.
Conclusion
Combination therapy of CAK and EGF promotes wound healing in partial-thickness burn wounds.

Keyword

Burns; Wound healing; Epidermal growth factor; Keratinocytes