Radiat Oncol J.  2011 Sep;29(3):191-198. 10.3857/roj.2011.29.3.191.

The role of squamous cell carcinoma antigen as a prognostic and predictive factor in carcinoma of uterine cervix

• Jeong BK
• Choi DH
• Huh SJ
• Park W
• Bae DS
• Kim BG

• KMID: 1995018
• DOI: http://doi.org/10.3857/roj.2011.29.3.191

Abstract

PURPOSE
Although the role of squamous cell carcinoma antigen (SCC-Ag) as a predictive and prognostic factor for uterine cervical cancer has been identified in previous studies, 1) the effective patient group of screening for recurrence with SCC-Ag, 2) the relationship between SCC-Ag and recurrence site, and 3) the relationship between the change of SCC-Ag and treatment outcome or recurrence have not been described.
MATERIALS AND METHODS
The study included 506 patients with histologically proven uterine cervical cancer between January 1994 and December 2010. We determining the serum SCC-Ag level before treatment and after treatment, and conducted a retrospective review of the patients' records. We evaluated the sensitivity and specificity of SCC-Ag for the detection of tumor recurrence by comparing biochemical recurrence with clinical recurrence.
RESULTS
The pretreatment SCC-Ag level and the proportion of patients over 1.5 ng/mL were higher in poor prognostic patient group. In the univariate and multivariate analysis, pretreatment SCC-Ag showed a statistically significant correlation with tumor size, International Federation of Gynecology and Obstetrics (FIGO) stage, pathology. In patients with biochemical recurrence vs. those without, 5-year DFS and OS were 27.6 vs. 92.7% (p < or = 0.001) and 53.7 vs. 92.5% (p < or = 0.001), respectively.
CONCLUSION
Our study reconfirmed the known function of pretreatment SCC-Ag, but could not confirm the function of biochemical response as a predictive factor for treatment and as a prognostic factor. There was no statistically significant relationship between SCC-Ag level and recurrence site. We confirmed the role of SCC-Ag as a follow-up tool for recurrence of disease and which patient groups SCC-Ag was more useful for.

Keyword

Cervical cancer; Squamous cell carcinoma antigen; Predictive factor; Prognostic factor

MeSH Terms

Antigens, Neoplasm
Carcinoma, Squamous Cell
Cervix Uteri
Female
Follow-Up Studies
Gynecology
Humans
Mass Screening
Multivariate Analysis
Obstetrics
Recurrence
Retrospective Studies
Sensitivity and Specificity
Serpins
Treatment Outcome
Uterine Cervical Neoplasms
Antigens, Neoplasm
Serpins