Korean J Obstet Gynecol.  2000 Mar;43(3):380-385.

The Clinical Significance of Squamous Cell Carcinoma Antigen as a Predictor of Nodal Metastasis in Early Stage Cervical Carcinoma

• Park SM
• Moon HS
• Kim SC

Abstract

OBJECTIVE
SCC-Ag(Squamous Cell Carcinoma Antigen) is a tumor marker for patients with squamous cell carcinoma of the uterine cervix. It has shown that the SCC-Ag was well related with the response of cancer therapy and course of cervical cancer. The aim of this study is to investigate whether the presence of pelvic lymph node metstasis can be predicted by the measurement of the preoperative SCC-Ag levels in the patients with early staged squamous cell carcinoma of cervix.
METHODS
The preoperative serum SCC-Ag levels were measured in 45 patients with stage I-II squamous cell carcinoma of cervix undergoing radical hysterectomy from September 1995 to December 1997. The serum SCC-Ag levels were analyzed for the clinicopathologic characteristics and other prognostic factors using univariate and multivariate analysis.
RESULTS
The serum SCC-Ag levels of the patients exhibited pelvic lymph node metastasis were above 4.8ng/ml. An elevated preoperative serum SCC-Ag level, and tumor size were independent predictors for the presence of lymph node metastasis(p<0.01).
CONCLUSION
The determination of the preoperative serum SCC-Ag levels provides a new prognostic factor in early staged cervical cancer.

Keyword

Cervical cancer; SCCA; Nodal metastasis

MeSH Terms

Carcinoma, Squamous Cell*
Cervix Uteri
Female
Humans
Hysterectomy
Lymph Nodes
Multivariate Analysis
Neoplasm Metastasis*
Uterine Cervical Neoplasms