J Gynecol Oncol.  2009 Sep;20(3):187-191. 10.3802/jgo.2009.20.3.187.

A case of neutrophilia related to a cytokine-producing relapsed squamous cell carcinoma of the uterine cervix arising from the rectovaginal septum

• Park G
• Park YJ
• Lim YS
• Ahn TG
• Han SJ

• KMID: 2173453
• DOI: http://doi.org/10.3802/jgo.2009.20.3.187

Abstract

Paraneoplastic neutrophilia caused by a squamous cell carcinoma of the uterine cervix has been seen rarely. We report a case of relapsed squamous cell carcinoma of the uterine cervix with severe neutrophilia, rapid tumor growth and aggressive clinical course, possibly due to autocrine stimulation of cell growth by G-CSF and IL-6 without other possible causes of neutrophilia.

Keyword

Squamous cell carcinoma; Uterine cervix; Paraneoplastic syndrome; G-CSF; IL-6

MeSH Terms

Carcinoma, Squamous Cell
Cervix Uteri
Female
Granulocyte Colony-Stimulating Factor
Interleukin-6
Paraneoplastic Syndromes
Granulocyte Colony-Stimulating Factor
Interleukin-6

Figure

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  Fig. 1 Serial monitoring data of WBC count, SCC, C-reactive protein (CRP), several cervicographic images (A, B, and E), transrectal ultrasound finding (C) and cytologic finding (D).

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  Fig. 2 Peripheral blood smear (A) and bone marrow aspiration smear (B) showed neutrophilia and reactive marrow, respectively (Wright-Giemsa stain, ×200).

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  Fig. 3 Microscopic finding of 2nd relapsed squamous cell carcinoma arising from rectovaginal septum (H-E stain, ×200 (A) and ×400 (B)).

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  Fig. 4 Results of RT-PCR assay revealed expression of mRNA of G-CSF (L1, 620 bp), G-CSF receptor (L2, 595 bp), IL-6 (L3, 408 bp), IL-6 receptor (L4, 251 bp) and GAPDH (L5, 351 bp). M, ΦX 174-Hae III digest size marker (TaKaRa Bio, Shiga, Japan).

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