Korean J Obstet Gynecol.  2012 Apr;55(4):269-273. 10.5468/KJOG.2012.55.4.269.

Combined small cell carcinoma and adenocarcinoma arising in uterine cervix

• Lee H
• Moon Y
• Kim H

• KMID: 1992625
• DOI: http://doi.org/10.5468/KJOG.2012.55.4.269

Abstract

We report here on a case of combined small cell carcinoma and adenocarcinoma arising on uterine cervix. The patient was a 39-year-old woman who presented with uterine cervical mass. Colposcopic biopsy confirmed as adenocarcinoma and radical hysterectomy was performed. The mass, measuring in about 2 cm in greatest diameter, was mainly endophytic growing. Histopathologically, the mass was consisted of well differentiated adenocarcinoma from 2 to 9 o'clock directions of uterine cervix. From 9 to 11 o'clock directions, small cell carcinoma was detected. On results of special stain and immunohistochemistry, mucin stains and carcinoembryonic antigen were positive in area of adenocarcinoma. Chromogranin A and synaptophysin, stain for neuroendocrine markers, were positive in region of small cell carcinoma. This case indicates that the small cell carcinoma and adenocarcinoma can simultaneously occur in uterine cervix.

Keyword

Carcinoma, Small cell; Adenocarcinoma; Cervix Uteri

MeSH Terms

Adenocarcinoma
Adult
Biopsy
Carcinoembryonic Antigen
Carcinoma, Small Cell
Cervix Uteri
Chromogranin A
Coloring Agents
Female
Humans
Hysterectomy
Immunohistochemistry
Mucins
Synaptophysin
Carcinoembryonic Antigen
Chromogranin A
Coloring Agents
Mucins
Synaptophysin

Figure

• 

  Fig. 1 Radiologic findings of the cervical tumor. (A) Pelvic magnetic resonance imaging shows the mass with increased signal intensity in the endocervical area of uterus. (B, C) Positron emission tomography (PET)/computerized tomography images show a hypermetabolic focus on lower uterine cervix. Note no evidence of distant tumor metastasis on PET scan.

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  Fig. 2 (A) On microscopic findings, the mounted section shows that well differentiated adenocarcinoma of the cervix infiltrating the stroma. The inset shows pseudostratified nuclei and cribriform pattern (A; H&E, ×200). (B) Small cell carcinoma shows confluent sheets of darkly staining neoplastic cells infiltrate the stroma on mounted section. The inset shows the loose packed tumor cells with scant cytoplasm and small foci of necrosis (B; H&E, ×200).

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  Fig. 3 Special stains and immunohistochemical stainings. (A) Adenocarcinoma (Periodic acid-schiff stain, ×400). (B) Carcinoembryonic antigen in adenocarcinoma (×400). (C) Chromogranin A in small cell carcinoma (×400). (D) Synaptophysin in small cell carcinoma (×400).

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