Korean J Obstet Gynecol.  2012 Apr;55(4):269-273. 10.5468/KJOG.2012.55.4.269.

Combined small cell carcinoma and adenocarcinoma arising in uterine cervix

Affiliations
  • 1Department of Pathology, Yangji General Hospital, Seoul, Korea. laghonda@naver.com
  • 2Department of Gynecology, Cheju Halla General Hospital, Jeju, Korea.
  • 3Department of Radiology, Cheju Halla General Hospital, Jeju, Korea.

Abstract

We report here on a case of combined small cell carcinoma and adenocarcinoma arising on uterine cervix. The patient was a 39-year-old woman who presented with uterine cervical mass. Colposcopic biopsy confirmed as adenocarcinoma and radical hysterectomy was performed. The mass, measuring in about 2 cm in greatest diameter, was mainly endophytic growing. Histopathologically, the mass was consisted of well differentiated adenocarcinoma from 2 to 9 o'clock directions of uterine cervix. From 9 to 11 o'clock directions, small cell carcinoma was detected. On results of special stain and immunohistochemistry, mucin stains and carcinoembryonic antigen were positive in area of adenocarcinoma. Chromogranin A and synaptophysin, stain for neuroendocrine markers, were positive in region of small cell carcinoma. This case indicates that the small cell carcinoma and adenocarcinoma can simultaneously occur in uterine cervix.

Keyword

Carcinoma, Small cell; Adenocarcinoma; Cervix Uteri
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