Korean J Pathol.  2009 Jun;43(3):206-211.

The Expression of Cyclooxygenase-2 and Survivin in Urinary Bladder Transitional Cell Carcinoma

• Jang TJ
• Lee KS

Abstract

BACKGROUND: The aim of this study was to investigate the expressions of cyclooxygenase-2 (COX-2) and survivin in bladder transitional cell carcinoma (TCC) that has different clinicopathologic characteristics, and we also wanted to determine if a relation exists between the COX-2 and survivin expressions.
METHODS
The expressions of COX-2 and survivin were investigated in 80 bladder TCCs by performing immunohistochemistry.
RESULTS
The normal bladder mucosa did not express COX-2 and survivin. COX-2 immunopositivity and cytoplasmic survivin immunopositivity were seen in 48% and 30% of bladder tumors, respectively. The expressions of COX-2 and survivin were closely related to the differentiation, depth and recurrence of bladder TCC, and there was a significant correlation in topographic distribution of COX-2 and survivin immunopositivity. In addition, COX-2 and survivin were predominantly expressed at the invasive front of tumors.
CONCLUSIONS
This data suggest that COX-2 and survivin may be involved in the progression of bladder TCC, and there is a close correlation between the expressions of COX-2 and survivin.

Keyword

Bladder cancer; Cyclooxygenase-2; Survivin

MeSH Terms

Carcinoma, Transitional Cell
Cyclooxygenase 2
Cytoplasm
Immunohistochemistry
Mucous Membrane
Recurrence
Urinary Bladder
Urinary Bladder Neoplasms
Cyclooxygenase 2