Korean J Pathol.  2011 Dec;45(6):596-603.

Prognostic Significance of Amplification of the c-MYC Gene in Surgically Treated Stage IB-IIB Cervical Cancer

Affiliations
  • 1Department of Hospital Pathology, The Catholic University of Korea College of Medicine, Seoul, Korea. klee@catholic.ac.kr
  • 2Department of Obstetrics and Gynecology, The Catholic University of Korea College of Medicine, Seoul, Korea.
  • 3Department of Preventive Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.

Abstract

BACKGROUND
Mutations of c-MYC have been described in cervical cancer. However, association between c-MYC gene status and its prognostic significance have not been clarified.
METHODS
Tissue microarray sections from 144 patients with stage IB-IIB cervical cancer treated by radical hysterectomy were analyzed by fluorescence in situ hybridization using a region-specific probe for c-MYC and a centromere-specific probe for chromosome 8.
RESULTS
Seventy five percent (108/144) of c-MYC gain and 6.9% (10/144) of c-MYC gene amplification were observed. c-MYC gene alteration was more frequently observed in squamous cell carcinoma than adenocarcinoma or adenosquamous carcinoma and were associated with low Ki67 labeling index (p=0.013). c-MYC amplification was not associated with clinicopathologic parameters except absence of bcl2 expression (p=0.048). Survival analysis revealed that patients with c-MYC amplification were significantly associated with higher risk of disease recurrence (p=0.007) and cancer related death (p=0.020). However, c-MYC gain was not associated with unfavorable outcome. Multivariate analysis proved c-MYC amplification as independent prognostic factors of shorter disease free survival and cancer-related death (p=0.028 and p=0.025, respectively).
CONCLUSIONS
c-MYC amplification, not gain, is an independent prognostic marker for shorter disease free and cancer specific survival in cervical cancer treated by radical hysterectomy.

Keyword

Uterine cervical neoplasms; In situ hybridization, fluorescence; MYC; Hysterectomy; Prognosis

MeSH Terms

Adenocarcinoma
Carcinoma, Adenosquamous
Carcinoma, Squamous Cell
Disease-Free Survival
Fluorescence
Genes, myc
Humans
Hysterectomy
In Situ Hybridization
In Situ Hybridization, Fluorescence
Multivariate Analysis
Prognosis
Recurrence
Uterine Cervical Neoplasms
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