Endocrinol Metab.  2012 Dec;27(4):299-302. 10.3803/EnM.2012.27.4.299.

Thyrotoxic Periodic Paralysis Induced by Dexamethasone

• Lee EJ
• Kim TK
• Kwon MJ
• Lee SH
• Park JH

• KMID: 1973793
• DOI: http://doi.org/10.3803/EnM.2012.27.4.299

Abstract

Thyrotoxic periodic paralysis (TPP) is a disease characterized by sudden onset and muscle paralysis. It occurs in the setting of hypokalemia of thyrotoxicosis. Cases of TPP induced by a glucocorticoid such as prednisolone or methylprednisolone have been reported. We report on two patients, each of whom received a dexamethasone injection and subsequently developed TPP. Both patients experienced sudden, flaccid paralysis of both extremities after the injection but recovered completely after receiving a potassium replacement. Laboratory results revealed thyrotoxicosis. The patients were diagnosed with Graves' disease and discharged after receiving treatment with methimazole and propranolol. This report provides the clinical description of TPP induced by dexamethasone injection. These cases suggest that clinicians must consider the presence of hyperthyroid disease in patients who develop acute paralysis after treatment with a glucocorticoid, even in the absence thyrotoxic symptoms. Furthermore, physicians should be aware that TPP can occur even in response to dexamethasone used for treatment of thyrotoxic crisis or Graves' ophthalmopathy.

Keyword

Dexamethasone; Hypokalemia; Paralysis; Thyrotoxicosis

MeSH Terms

Dexamethasone
Extremities
Graves Disease
Humans
Hypokalemia
Methimazole
Methylprednisolone
Muscles
Paralysis
Potassium
Prednisolone
Propranolol
Thyroid Crisis
Thyrotoxicosis
Dexamethasone
Methimazole
Methylprednisolone
Potassium
Prednisolone
Propranolol

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