J Korean Acad Periodontol.  2004 Mar;34(1):149-162. 10.5051/jkape.2004.34.1.149.

Space-maintaining and osteopromotive effect of freezedried bone graft in the procedure of GBR

• Hong SM
• Herr Y
• Kwon YH
• Park JB

• KMID: 1962487
• DOI: http://doi.org/10.5051/jkape.2004.34.1.149

Abstract

This study was performed to evaluate the effect of freeze-dried bone graft on space-making capacity and bone formation in the procedure of guided bone regeneration with titanium reinforced ePTFE membrane. After decortication in the calvaria, GBR procedure was performed on 8 rabbits with titanium reinforced ePTFE membrane filled with human FDBA(Rocky Mountain Tissue Bank, Aurora Co., USA). Decortication was performed to induce the effect of bone forming factor from bone marrow. The animals were sacrificed at 2 weeks, 4 weeks, 8 weeks and 12 weeks after the surgery. Non-decalcified specimens were processed for histologic analysis. The results of this study were as follows: 1. Titanium reinforced-ePTFE membrane was biocompatable and capable of maintaining the space-making. 2. FDBA particle was surrounded with connective tissues but there was no evidence on new bone formation. 3. FDBA particle resorbed continuously but it remained until 12weeks after the surgery. Within the above results, TR-ePTFE membrane could be used effectively for Guided bone regeneration but It was assumed that FDBA does not appear to contribute to bone formation.

Keyword

osteopromotive effect; freeze-dried bone graft

MeSH Terms

Animals
Bone Marrow
Bone Regeneration
Connective Tissue
Humans
Membranes
Osteogenesis
Rabbits
Skull
Tissue Banks
Titanium
Transplants*
Titanium