J Korean Acad Periodontol.  2004 Dec;34(4):711-722. 10.5051/jkape.2004.34.4.711.

Osteopromotive effect of Titanium Reinforced-ePTFE membrane

• Lee J
• Kwon YH
• Park JB
• Herr Y
• Chung JH
• Kim CK

• KMID: 1962428
• DOI: http://doi.org/10.5051/jkape.2004.34.4.711

Abstract

The purpose of this study is to evaluate the regenerated bone histollogically using titanium reinforced ePTFE(TR-ePTFE) membrane and to investigate cell occlusiveness, wound stabilization and tissue integration of TR-ePTFE membrane. Adult male rabbits (mean BW 2kg) and TR9W (W.L.Gore&Associate.INC,USA) were used in this study. Intramarrow penetration defects were surgically created with round carbide bur(HP long #6) on calvaria of rabbits. TR-ePTFE membrane was applied to defect. Then guided bone regeneration was carried out using TRePTFE membrane and resorbable suture. At 2,4,8,12 weeks after the surgery, animals were sacrificed. Nondecalcified specimens were processed for histologic analysis. The result and conclusion of this study were as follows: 1. TR-ePTFE membrane had good ability of biocompatibility and cell occlusiveness. 2. space making for guided bone regenerayion was good at TR-ePTFE membrane. 3. Tissue integration was not good at TR-ePTFE membrane. So, wound stabilization was not good. 4. At 8 weeks, 12 weeks after GBR procedure, bone formation was seen. From the above results, TR -ePTFE membrane fixed tightiy on alveolar bone might be recommended for the early bone formation.

Keyword

TR-ePTFE; cell occlusiveness; wound stabilization; tissue integration

MeSH Terms

Adult
Animals
Bone Regeneration
Humans
Male
Membranes*
Osteogenesis
Rabbits
Skull
Sutures
Titanium*
Wounds and Injuries
Titanium